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Congenital leukemia is a very rare malignancy of childhood with a poor prognosis. The incidence is nearly 1 in 5 million live births. The majority of cases are acute myeloblastic leukemia with trisomy. Clinical manifestations are usually leukocytosis, petechia, ecchymosis, cutaneous nodules, hepatosplenomegaly and central nervous system symptoms. 2...
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... was heard. Laboratory evaluations were as following: leucocyte count 40410/mm 3 , hemoglobin 9.2 gr/dl, hematocrit 27.4%, platelet count 175000/mm 3 , LDH 2281 U/L, GGT 290 U/L. On peripheral blood smear there were 20% blasts ( Figure 1). Abdominal ultrasonography was normal except hepatosplenomegaly. Viral serology tests (VDRL, CMV IgM and IgG, Toxoplazmosis IgM and IgG, Rubella IgM and IgG, anti-HIV) were in normal ranges. Bone marrow aspiration yielded 29% blasts (Figure 2). After flow cytometry analysis (CD7 90%, CD13 23.8%, CD33 73.4%, CD34 64.5%, CD117 60.5%, HLA-DR 77.7%, MPO 55.4%) the patient diagnosed as acute myeloblastic leukemia M1 (AML M1). Bone marrow karyotype analysis revealed chromosome numbers varied between 45 and 47 in 16 of 20 metaphase and in these metaphases trisomy 21 was detected. Cytogenetic analysis were negative for t (9;22), t (15;17), t (8;21), inv(16). On the seventh day of hospitalization, due to the edema, weight gain, respiratory distress and tachycardia, the fluid therapy of the patient was restricted. She was transfused for anemia. ...
