Figure - available from: The Journal of International Medical Research
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Biopsy of the left gastrocnemius muscle showing (a, b) endomysial infiltration of mononuclear cells surrounding myofibers and perivascular infiltration of mononuclear cells (arrows) with myofiber size variability. (c, d) Immunohistochemical staining of CD3 showing T cells invading the endomysium. No rimmed vacuoles were found in the biopsy specimens. (a, c) ×10 magnification. (b, d) ×30 magnification.
Source publication
Polymyositis is a subgroup of idiopathic inflammatory myopathies characterized by symmetric proximal limb weakness and chronic skeletal muscle inflammation. We herein report the first case of bilateral leg pain and unilateral calf atrophy caused by polymyositis accompanying lumbar spinal stenosis and disc herniation. A 52-year-old man presented wit...
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Purpose:
We compared the clinical effects of Neurotropin, limaprost alfadex, and a combination of both drugs for lumbar spinal stenosis (LSS) with low back pain (LBP).
Methods:
We conducted a multicenter, randomized, active-controlled, open-label trial from March 2021 to May 2022. Participants were patients diagnosed with LSS by MRI and were ran...
Citations
... The differential diagnosis of unilateral calf atrophy includes several medical disorders, including lumbosacral radiculopathy, asymmetric myopathy/dystrophy, late effect of lower extremity compartment syndrome, peroneal tendinopathy, Baker's cyst resulting in tibial compression, amyotrophic lateral sclerosis, polymyositis, and disuse atrophy [1][2][3]. Of these etiologies of unilateral calf atrophy, lumbar radiculopathies of L5 and S1 are the most common ones [2]. ...
... The differential diagnosis of unilateral calf atrophy includes several medical disorders, including lumbosacral radiculopathy, asymmetric myopathy/dystrophy, late effect of lower extremity compartment syndrome, peroneal tendinopathy, Baker's cyst resulting in tibial compression, amyotrophic lateral sclerosis, polymyositis, and disuse atrophy [1][2][3]. Of these etiologies of unilateral calf atrophy, lumbar radiculopathies of L5 and S1 are the most common ones [2]. In addition to nerve compression by a Baker's cyst, other compressive pathologies include ganglion of the tibial nerve, tendinous arch of the soleus muscle, fibrous bands between the two heads of the gastrocnemius muscle, and tibial nerve tumors [4]. ...
... Differentiating between diverse causes of unilateral calf atrophy may prove challenging. In Baek et al.'s case report of unilateral calf atrophy and bilateral leg pain, the patient was diagnosed with polymyositis accompanying lumbar spinal stenosis and disc herniation [2]. As polymyositis involved the distal muscles of the lower extremities, it was often difficult to distinguish between polymyositis and spinal stenosis without electrodiagnostic (EDX) testing. ...
Unilateral calf atrophy may result from several medical conditions, such as lumbar radiculopathy, asymmetric myopathy/dystrophy, a Baker’s (popliteal) cyst leading to tibial nerve compression, and disuse atrophy. We present a case series of four patients with unilateral calf atrophy, including chronic neurogenic atrophy (benign focal amyotrophy, one patient), tibial nerve compression at the popliteal fossa by a Baker’s cyst (one patient), and disuse atrophy (two patients). All four patients underwent electrodiagnostic (EDX) studies, and two of them had denervation changes of the gastrocnemius. One patient underwent an ultrasound (US), which revealed a large cyst in the popliteal fossa causing compression of the tibial nerve. The differential diagnosis of unilateral calf atrophy as well as diagnostic techniques to confirm the underlying pathology are described. EDX and US studies are useful in differentiating between the varied conditions that may cause asymmetric calf muscle wasting.
