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The clinical success of islet transplantation is limited by factors including acute ischemia, stress upon transplantation, and delayed vascularization. Islets experience high levels of oxidative stress due to delayed vascularization after transplantation and this can be further aggravated by their encapsulation and undesirable cell-biomaterial inte...
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Context 1
... this study, we investigate the cell-biomaterial interaction using a series of different polymers with particular attention given to oxidative stress and islet function (determined by gene expression-related changes) in rodent pancreatic endocrine cells. All biomaterials studied are considered to be biocompatible based on past performance in in vivo studies and, in some cases, their current clinical use (Table 1). We hypothesize that different polymeric biomaterials can induce different levels of oxidative stress in the blood glucose-controlling pancreatic endocrine cells. ...Context 2
... thermoplastic polymers were preselected on the basis of their past performance and, in some cases, their clinical use ( Table 1). The ideal biomaterial for an encapsulation device would be elastic for implantation and hydrophilic to enhance insulin and glucose diffusion [17]. ...Context 3
... this study, we investigate the cell-biomaterial interaction using a series of different polymers with particular attention given to oxidative stress and islet function (determined by gene expression-related changes) in rodent pancreatic endocrine cells. All biomaterials studied are considered to be biocompatible based on past performance in in vivo studies and, in some cases, their current clinical use (Table 1). We hypothesize that different polymeric biomaterials can induce different levels of oxidative stress in the blood glucose-controlling pancreatic endocrine cells. ...Similar publications
The clinical success rate of islet transplantation, namely independence from insulin injections, is limited by factors that lead to graft failure, including inflammation, acute ischemia, acute phase response, and insufficient vascularization. The ischemia and insufficient vascularization both lead to high levels of oxidative stress, which are furth...
