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Background: The Surviving Sepsis Campaign recommends the administration of antibiotics within 1 hour of triage time in sepsis patients. The
purpose of this study was to determine the factors affecting the time to first dose antibiotics in sepsis patients presenting to the emergency
department (ED).
Methods: We conducted a prospective observational...
Contexts in source publication
Context 1
... (84.8%) were triaged to priority 1, and the most common comorbidities were diabetes mellitus 130 (31.7%) and hypertension 103 (25.1%). The baseline characteristics are shown in Table 1. The median time of door to antibiotic administration was 50 minutes (IQR: 40-90), and 279 (68%) patients were administered the antibiotic within 1 hour. ...Context 2
... (84.8%) were triaged to priority 1, and the most common comorbidities were diabetes mellitus 130 (31.7%) and hypertension 103 (25.1%). The baseline characteristics are shown in Table 1. The median time of door to antibiotic administration was 50 minutes (IQR: 40-90), and 279 (68%) patients were administered the antibiotic within 1 hour. ...Citations
Objective:
to evaluate the association between risk classification and door-to-antibiotic time in patients with suspected sepsis.
Method:
retrospective cohort study, with a sample of 232 patients with suspected sepsis treated at the emergency department. They were divided into 2 groups: with and without risk classification. Once the door-to-antibiotic time was identified, one-way analysis of variance was performed with Bonferroni post hoc test or independent Student's t-test for continuous quantitative variables; Pearson correlation tests, point-biserial correlation or biserial correlation for association analyses; and bootstrap procedure when there was no normal distribution of variables. For data analysis, the Statistical Package for the Social Sciences software was used.
Results:
the door-to-antibiotic time did not differ between the group that received risk classification compared to the one that was not classified. Door-to-antibiotic time was significantly shorter in the group that received a high priority risk classification.
Conclusion:
there was no association between door-to-antibiotic time and whether or not the risk classification was performed, nor with hospitalization in infirmaries and intensive care units, or with the length of hospital stay. It was observed that the higher the priority, the shorter the door-to-antibiotic time.
Objetivo: avaliar a associação entre a realização de classificação de risco e o tempo porta-antibiótico no paciente com suspeita de sepse. Método: estudo de coorte retrospectivo, com amostra de 232 pacientes com suspeita de sepse atendidos no pronto atendimento. Foram distribuídos em 2 grupos: com e sem classificação de risco. Identificado o tempo porta-antibiótico, realizou-se análise de variância de um fator com post hoc de Bonferroni ou teste T-Student independente para variáveis quantitativas contínuas; testes de correlação de Pearson, correlação bisserial por pontos ou correlação bisserial para análises de associação; e procedimento de bootstrap quando não havia distribuição normal de variáveis. Para a análise dos dados foi utilizado o software Statistical Package for the Social Sciences. Resultados: o tempo porta-antibiótico não diferiu entre o grupo que recebeu classificação de risco comparado ao que não foi classificado. O tempo porta-antibiótico foi significativamente menor no grupo que recebeu classificação de risco de alta prioridade. Conclusão: não houve associação entre o tempo porta-antibiótico e a realização ou não da classificação de risco, tampouco com internação em enfermaria e em unidade de terapia intensiva, ou com o tempo de internação hospitalar. Observou-se que quanto maior a prioridade, menor o tempo porta-antibiótico.
Objective: to evaluate the association between risk classification and door-to-antibiotic time in patients with suspected sepsis. Method: retrospective cohort study, with a sample of 232 patients with suspected sepsis treated at the emergency department. They were divided into 2 groups: with and without risk classification. Once the door-to-antibiotic time was identified, one-way analysis of variance was performed with Bonferroni post hoc test or independent Student’s t-test for continuous quantitative variables; Pearson correlation tests, point-biserial correlation or biserial correlation for association analyses; and bootstrap procedure when there was no normal distribution of variables. For data analysis, the Statistical Package for the Social Sciences software was used. Results: the door-to-antibiotic time did not differ between the group that received risk classification compared to the one that was not classified. Door-to-antibiotic time was significantly shorter in the group that received a high priority risk classification. Conclusion: there was no association between door-to-antibiotic time and whether or not the risk classification was performed, nor with hospitalization in infirmaries and intensive care units, or with the length of hospital stay. It was observed that the higher the priority, the shorter the door-to-antibiotic time.
The plants are rich of metabolites that can be enter many fields of life, called phytochemicals. The most important features of phytochemicals are shown in human health. The natural components of plants can exhibit anti-diabetic, anti-inflammation, anti-viral, antifungal, antibacterial, antioxidant, and other properties with benefits to the human health. The bacterial resistance to the traditional drugs has opened the area of research to overcome this serious problem. Another contributor to health problems is oxidative stress, which is caused by an inadequate supply of antioxidants to counteract the free radicals. Lemon (citrus limon) has shown to contain wide spectrum of phytochemicals with therapeutic behavior. Our study was designed to investigate two types of lemon peels extract on microbes growth and free radical scavenging, one as pure peel oil, and the other is an extract by methanol. Our findings demonstrate that an extract of Iraqi lemon peel is an effective microbicidal agent, with significant growth suppression against Escherichia coli, Klebsiella sp., Staphylococcus epidermidis, Staphylococcus aureus, as well as Candida albicans. The ethanolic extract of the lemon peels has shown to be more effective against the growth of microbes. Furthermore, Iraqi lemon peel extract of both oil and ethanolic have exhibited an antioxidant activity comparable to the pure ascorbic acid. This features of lemon peels make it a very good candidate for natural therapeutic medicine.
