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B : Size Distribution of 3A) F4, 3B) F8 Vesicle Morphology: 

B : Size Distribution of 3A) F4, 3B) F8 Vesicle Morphology: 

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The present work deals with the preparation of Glimeperide (GP) ethosomes and study of effect of alcohol and phospholipid on systemic as well as topical delivery of drug. Glimepride loaded ethosomes were prepared by cold method by using different concentrations of alcohol (20-30% w/w) and soya lecithin (3.5-4% w/w) in different ratios and propylene...

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Context 1
... The vesicle size of ethosomes ranges from 22 to 105 nm. On increasing the concentration of phospholipid from 3.5 to 4% w/w, the size of vesicle was increased and on increasing the concentration of ethanol and isopropyl alcohol from 20 to 30% w/w, the size of vesicle decreases. From F1 to F8 the size of vesicle increases on increasing the concentration of phospholipid (Table 2). From F1 to F4 in ethanol and F5 to F8 in isopropyl alcohol shows that on increasing the concentration of ethanol and isopropyl alcohol from 20 to 30% w/w the size of vesicle decreases (Fig. 3). This may be due to the formation of a phase with interpenetrating hydrocarbon chain. The decrease in particle size is due to the ethanol and isopropyl alcohol causing a modification of the net charge of the system and some degree of steric stabilization. The vesicle shape of all the ethosomal formulations was found to be spherical with the smooth surface as shown in the Fig. 4. The turbidity of ethosomal formulation in ethanol and isopropyl alcohol was found to be in the range of 60±0.1 to 110±0.05 and 102±0.20 to 171±0.20 NTU (Fig. 5). The data shows that on increasing the ethanol concentration from 20 to 30% w/w the turbidity increases from F1 to F8. Zeta potential measurement study was observed as shown in the Table 2. ...
Context 2
... The vesicle size of ethosomes ranges from 22 to 105 nm. On increasing the concentration of phospholipid from 3.5 to 4% w/w, the size of vesicle was increased and on increasing the concentration of ethanol and isopropyl alcohol from 20 to 30% w/w, the size of vesicle decreases. From F1 to F8 the size of vesicle increases on increasing the concentration of phospholipid (Table 2). From F1 to F4 in ethanol and F5 to F8 in isopropyl alcohol shows that on increasing the concentration of ethanol and isopropyl alcohol from 20 to 30% w/w the size of vesicle decreases (Fig. 3). This may be due to the formation of a phase with interpenetrating hydrocarbon chain. The decrease in particle size is due to the ethanol and isopropyl alcohol causing a modification of the net charge of the system and some degree of steric stabilization. The vesicle shape of all the ethosomal formulations was found to be spherical with the smooth surface as shown in the Fig. 4. The turbidity of ethosomal formulation in ethanol and isopropyl alcohol was found to be in the range of 60±0.1 to 110±0.05 and 102±0.20 to 171±0.20 NTU (Fig. 5). The data shows that on increasing the ethanol concentration from 20 to 30% w/w the turbidity increases from F1 to F8. Zeta potential measurement study was observed as shown in the Table 2. ...

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