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Primary sclerosing cholangitis is a rare cause of cholestasis caused by progressive inflammation and fibrosis of both intrahepatic and extrahepatic bile ducts leading to multifocal ductal strictures. Herein, we report a case of primary sclerosing cholangitis and inflammatory bowel disease. The concomitant diagnosis of these two diseases is not typi...
Citations
... On the other hand, oxidative stress and its associated complications could play a significant role in this situation [11]. Several case reports of cholestasis/cirrhosis-induced anemia have been published [112][113][114]. Hypochromic microcytic anemia seems to be humans' most prevalent phenotype of cholestasis/cirrhosis-induced anemia [112]. ...
... Several case reports of cholestasis/cirrhosis-induced anemia have been published [112][113][114]. Hypochromic microcytic anemia seems to be humans' most prevalent phenotype of cholestasis/cirrhosis-induced anemia [112]. In the current study, we detected microcytic hypochromic RBCs in the BDL rats 42 days after the BDL operation (Fig. 5). ...
... In the current study, we detected microcytic hypochromic RBCs in the BDL rats 42 days after the BDL operation (Fig. 5). This finding is in line with other studies that indicate microcytic anemia as a prevalent type of morphological change of RBCs in cirrhosis [112]. On the other hand, detecting a significant number of polychromasia erythrocytes was another interesting finding that was detected 28 and 42 days after BDL induction (Fig. 5). ...
Aim of the study:
Cholestasis/cirrhosis could induce erythrocyte lysis. The incidence of various types of anemia in cirrhosis is approx. 75%. Several studies have mentioned the pivotal role of oxidative stress in this complication. Taurine (TAU) is the human body's most abundant free amino acid. TAU is known as a robust cell membrane stabilizer. Many studies have mentioned that TAU could counteract oxidative stress in various experimental models. The current study was intended to evaluate the effect of TAU on erythrocytes in cirrhotic rats.
Material and methods:
Bile duct ligation (BDL) surgery was carried out on rats. Then, complete blood count (CBC), hemoglobin (Hgb), hematocrit (HTC), and erythrocytes' G6PD, catalase (CAT), and superoxide dismutase (SOD) activity were measured. Moreover, biomarkers of oxidative stress were assessed, and the erythrocytes' morphological changes were monitored in the cirrhotic mice exposed to TAU (0.25%, 0.5%, and 1% w : v in drinking water).
Results:
Significant changes in the assessed erythrocyte parameters (G6PD activity, Hgb, HTC, and erythrocyte count) and red blood cells (RBC) morphological alterations were detected on day 42 after BDL surgery. Biomarkers of oxidative stress also did not change at the time points, except on post-BDL days 28 and 42. A significant decrease in blood parameters was evident at post-BDL day 42. All doses of TAU (0.25%, 0.5%, and 1% w : v in drinking water) significantly improved erythrocyte parameters and encountered oxidative stress in the erythrocytes of cirrhotic animals.
Conclusions:
These data indicate that TAU could be a safe agent to mitigate cirrhosis-induced erythrocyte damage and anemia. Further investigations are necessary to prove this in clinical settings.
