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Atomic force microscopy imaging of model pulmonary surfactant monolayers with SP-B and SP-C at different surface pressures. The scale bars equal to 5, 2, and 2 µm at 35, 45, and 55 mN/m, respectively.

Atomic force microscopy imaging of model pulmonary surfactant monolayers with SP-B and SP-C at different surface pressures. The scale bars equal to 5, 2, and 2 µm at 35, 45, and 55 mN/m, respectively.

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Figure 2: Simulated surface pressure-area isotherm for the monolayer...
Figure 3: Diffusion coefficients of lipids as a function of surface...
Figure 4: The average thickness of the monolayers and the position of...
Figure 5: The fraction of the lipid acyl chains that show L c -like...
+1 Figure 6: Atomic force microscopy imaging of model pulmonary surfactant...
Surfactant Proteins SP-B and SP-C in Pulmonary Surfactant Monolayers: Physical Properties Controlled by Specific Protein–Lipid Interactions
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  • Dec 2022
The lining of the alveoli is covered by pulmonary surfactant, a complex mixture of surface-active lipids and proteins that enables efficient gas exchange between inhaled air and the circulation. Despite decades of advancements in the study of the pulmonary surfactant, the molecular scale behavior of the surfactant and the inherent role of the numbe...
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... more than 1 nm occur in the acyl chains region, corresponding to an increased chain ordering. The head groups also contribute a little by extending towards the aqueous phase. Considering the individual lipid components in the model surfactant, across all surface pressures, the POPG head group seems to reside slightly below those of DPPC and POPC (Fig. S6). Still, on average all the phospholipids show similar trends, whereas CHOL shifts slightly away from the interface upon compression 14 . CC-BY 4.0 International license available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is ...
Context 2
... atomic force microscopy (AFM) measurements of films transferred to a mica surface. For these measurements, we used the same lipid mixture as in our simulations, and either SP-B or SP-C was added (see Methods for details). The corresponding AFM data for the protein-free systems were reported in our previous work. 11 The AFM images are assembled in Fig. ...