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Recent advances in edible coatings (EC) are helpful in extending shelf life, resolving fruit safety issues, and maintaining quality of fresh fruits. There is dire need to evaluate the cost-effective and environmental friendly natural plant extracts for extending the shelf life of fresh-cut fruits. Aloe vera gel (AVG) is one of the best edibles and...
Citations
... The animals were divided into four groups, each containing ten animals with almost equal body weights, and dosed orally as follows: Group I: animals were given distilled water and served as a control; Group II: animals were given MLE at a dose of 200 mg/kg b.w. for 28 days in accordance with the procedure of Salama et al. [31]; Group III: animals were given an oral dose of TMX (≈1/10 LD 50 = 87.73 mg TMX/kg b.w. for 28 days), in line with the procedure of Saadi et al. [32]; and Group IV: animals were orally administered MLE plus TMX for 28 days in the same manner as in the second and third groups. ...
Thiamethoxam (TMX) exerts pronounced insecticidal effects against a wide variety of economically imperative pests. However, the administration of TMX in experimental animals induced notable adverse effects on the function of various organs. The purpose of this study was to assess whether TMX induced hematological, biochemical, and genetic alterations and, if so, the potential ameliorative effects on them of Moringa oleifera leaf extract (MLE) in male mice. Animals were orally administered TMX (≈1/10 LD50) daily either alone or with MLE (200 mg/kg b.w.) for 28 successive days. Blood was collected to evaluate the hematological profile and serum levels of Aspartate Aminotransferase (AST), Alanine aminotransferase (ALT), alkaline phosphatase (ALP), albumin, creatinine, uric acid, and urea. Liver and kidney cells were used to assess the Malondialdehyde (MDA) content and antioxidant enzymes. DNA integrity was estimated also in the liver and kidney using comet and colorimetric diphenylamine assays. Results revealed that TMX exhibited significant changes in the hematological profile and liver and kidney functions. Besides, TMX significantly raised the MDA content and DNA damage in both two of these organs. In contrast, TMX reduced the antioxidant activities in the cells of both liver and kidney. Meanwhile, Moringa extract combined with TMX significantly attenuated the deleterious findings of TMX. Specifically, it improved the TMX-induced hematological changes, liver and kidney function alterations, oxidative stress, and DNA damage rate. It can be concluded that TMX had adverse effects on different cells of male mice, but MLE successfully ameliorated TMX’s hematological and hepatorenal toxicity.
Background:
Aloe vera is commonly used in the primary health care of human beings since time immemorial. It is an herb widely used in various traditional systems of medicine worldwide. Systematic and scientific investigation on A. vera as a medicinal plant has drawn considerable attention, and many laboratories are involved in isolation, characterization and evaluation of phytoconstituents for their nutraceutical and pharmaceutical applications.
Purpose:
The aim of this study was to provide an overview of the phytochemical, biological and medicinal attributes of A. vera against various diseases with special emphasis on underlying mechanisms of action.
Methods:
PubMed, EBOSCO host, Science Direct, Scopus, and Cochrane library databases were utilized to search literature published between1977 and 2019 (till March). Major keywords used in various combinations included: Aloe vera, phytochemistry, metabolism, pharmacological activity, prevention, treatment, health, disease, in vivo, in vitro, and clinical studies.
Results:
Various biological and pharmacological activities of A. vera, such as antioxidant, anti-inflammatory, immuno-modulatory, antimicrobial, antiviral, antidiabetic, hepatoprotective, anticancer, and skin-protective and wound-healing responses, have been attributed to the presence of many active compounds, including anthraquinones, anthrones, chromones, flavonoids, amino acids, lipids, carbohydrates, vitamins and minerals.
Conclusion:
Based on various preclinical studies, A. vera constituents have enormous potential to prevent and treat various diseases. Randomized clinical trials are needed to understand the full therapeutic potential of this unique medicinal plant.
