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The diabetic foot is defined as the presence of ulcer, infection, or deep tissue breakdown in a foot of a person with diabetes, in association with peripheral neuropathy and/or peripheral arterial disease. Diabetic foot ulcers, the leading cause of diabetic patients’ hospitalization, are among the most common, serious, and costly complications of d...
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Background: Almost 80% population of diabetic foot are from low to middle income countries like India, a country with second largest number of diabetic populations. Prevalence of diabetes mellitus in India is 9.3%. Lower extremity diseases, including peripheral neuropathy, peripheral arterial disease, and foot ulceration, is twice common in diabeti...
Background: Globally, about 425 million people are suffering from diabetes mellitus (DM) which will be about 629
million by 2045. India is popularly known as “World Diabetes Capital” and is presently home of about 72.9 million
diabetes patients. Poorly managed DM will increase the burden of both microvascular and macrovascular complications.
One of...
Background:
Diabetic foot ulcers are serious and challenging wounds associated with high risk of infection and lower-limb amputation. Ulcers are deemed neuroischaemic if peripheral neuropathy and peripheral artery disease are both present. No satisfactory treatment for neuroischaemic ulcers currently exists, and no evidence supports one particular...
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Objective
The aim of this study was to investigate the effect of allicin on wound healing in an experimental diabetes model.
Method
In this randomised controlled study, 50 Wistar albino rats (25 females, 25 males) each weighing 200–300g were used. To develop the diabetes model, 30 rats were induced with 50mg/kg streptozotocin (STZ); 20 rats were not induced in order to compare diabetic and nondiabetic rats. The diabetic rats were divided into three groups, according to dressing material used (allicin, physiological serum and control, where no dressing was used), and the nondiabetic rats were divided into two groups (allicin and control, where no dressing was used). The wound area was calculated and recorded on days 0, 7, 14 and 21. In addition, biopsies were taken from the wound area on days 0, 7, 14 and 21 and used for microscopic examination. Day 0 was used as a reference to calculate wound healing percentage.
Results
On days 7 and 14, there were statistically significant differences between groups. Wound surface areas were smaller in the allicin group than in other groups on days 7 and 14. There were no statistically significant differences between the groups on day 21. In addition, it was determined that neutrophil, mononuclear cell, intraepithelial oedema and dermal oedema density were lower and fibroblast, angiogenesis and collagen density were higher in the allicin groups on days 7 and 14.
Conclusion
In this study, allicin was found to be potentially effective on wound healing. Future research should be conducted in order to clarify how it affects wound healing.
