Table 2 - uploaded by Sergey Dobretsov
Content may be subject to copyright.
Source publication
Marine macroalgae produce a wide variety of biologically-active metabolites that have been developed into commercial products, such as antibiotics, immunosuppressive, anti-inflammatory, cytotoxic agents, and cosmetic products. Many marine algae remain clean over longer periods of time, suggesting their strong antifouling potential. Isolation of bio...
Similar publications
The present investigation was carried to determine the phytochemicals of Sargassum linearifolium (Turner) C.Ag using UV-Visible spectroscopy, FTIR spectroscopy and HPLC. The UV-Visible spectrum of chloroform extract of Sargassum linearifolium (Turner) C.Ag. showed the peaks at the nm of 325, 412, 537, 610, 668, 882, 962, 1015 and 1059 with the abso...
Citations
... To face the potential risks of currently used biocides, several studies have reported the potential of natural compounds extracted from marine and terrestrial sources, with interesting AF properties [12][13][14][15][16][17]. In addition to them, some nature-inspired synthetic AF derivatives have also been developed and shown to display eco-friendly features and low ecotoxicity [18][19][20][21][22]. ...
Marine biofouling, caused by the deposition and accumulation of marine organisms on submerged surfaces, represents a huge concern for the maritime industries and also contributes to environmental pollution and health concerns. The most effective way to prevent this phenomenon is the use of biocide-based coatings which have proven to cause serious damage to marine ecosystems. Several research groups have focused on the search for new environmentally friendly antifoulants, including marine and terrestrial natural products and synthetic analogues. Some of these compounds have been incorporated into marine coatings and display interesting antifouling activities caused by the interference with the biofilm-forming species as well as by the inhibition of the settlement of macroorganisms. This review highlights the proof-of-concept studies of emerging natural or synthetic antifouling compounds in coatings, from lab-made to commercial ones, performed between 2019 and 2023 and their results in the field or in in vivo laboratorial tests.
... The natural process of epibiotic organism colonising and growing excessively on submerged surfaces is known as "biofouling" (Heidarian et al., 2019). Due to its impact on ship hulls, fuel systems, and marine aquaculture equipment, biofouling, which leads to heightened drag resistance, elevated water content in fuel systems, and obstruction of various components, has garnered signi cant attention from the maritime sectors (Dahms & Dobretsov, 2017). The maritime sectors have allocated signi cant nancial resources for the upkeep and removal of marine fouling on offshore facilities and other marine equipment. ...
... About 16 percent of all publications about antifouling compounds from algae were produced by Chinese researchers; the remaining 76 percent were produced by researchers in the UK, France, Germany, Japan, and the United States. (Dahms & Dobretsov, 2017). ...
... While some recent systematic literature reviews have been published, they have mainly addressed particular subjects like antifouling compounds derived from marine macroalgae (Dahms & Dobretsov, 2017) and marine antifouling assays (Briand, 2009). Consequently, we made the decision to carry out an extensive scientometric analysis of studies that examined the anti-fouling marine coating in seaweed research. ...
One of the most exciting alternatives to dangerous paints based on heavy metals is the development of coatings that act as natural anti-settlement agents and prevent fouling by utilising active ingredients found in seaweed. This is why understanding the field's extraordinary growth—which encompasses a wide range of topics like marine fouling, anti-biofilm, anti-fouling, future bioprospecting, and marine coating in general—requires evaluating the current body of research on seaweed's antifouling. For this kind of evaluation, summaries of description and co-citation analyses are both required to understand the scope of this study and identify research gaps. Given the topic's importance and the fact that it has received insufficient attention, this study fills a void in seaweed’s antifouling research. Using the CiteSpace software, we examined seaweed’s antifouling research published in the WOSCC database between 1991 and 2022. This produced 13,197 records in total, with a focus on factors in scientomectric analysis using CiteSpace software. We also discovered that seaweed paper increased exponentially, with productive countries (UK, Germany, and Brazil) contributing the most. The author from Brazil, French and the UK are the world's top productive author on antifouling of seaweed study. The most productive journal, unsurprisingly, was Seaweed. We discovered that keywords like "marine macroalgae," secondary metabolites" and "algae" were among the most cited and prominent in antifouling in seaweed research scope. As far as our understanding extends, this study represents the inaugural utilization of scientometric analyses employing CiteSpace software to pinpoint trends within antifouling research related to seaweed.
... Furthermore, biofilm was known as the bacteria's predominant stage in their life cycle, and hence, antibiofilm assay could be considered a preliminary screening for antifouling activity. According to Dahms and Dobretsov (2017), the isolation and characterization of naturally occurring antifouling compounds could pave the way to the production of green natural product-based antifouling paint. Moreover, most of the natural products isolated from marine organisms came from their low or non-toxic secondary metabolites. ...
The fouling phenomenon grabbed global attention and caused huge economic losses specifically in marine-related industries. Sessile behavior exposed the sponge to the risk of fouling. However, their bodies remained free from foulers, which were attributed to the chemical defense system. The objectives of this study were to determine the antibiofilm activity of the marine sponge, Stylissa carteri, and to characterize the isolated compound involved. The antibiofilm activity of S. carteri methanolic crude extract (MCE) and fractions was tested against biofilm-producing bacteria, Pseudomonas aeruginosa, using two different modes of crystal violet biofilm assays: preventive and detachment. Besides that, the disc-diffusion test was conducted to screen the antibacterial activity against gram-positive and gram-negative bacteria while a cytotoxicity assay was conducted on the HepG2 cell line. Bioassay-guided fractionation was carried out using vacuum liquid chromatography (VLC) and solid phase extraction using a C18 Sep-Pak Cartridge. The crystal compound was isolated and characterized through thin-layer chromatography (TLC), Fourier transform infrared (FTIR) spectroscopy, liquid chromatography-mass spectrometry (LCMS), and nuclear magnetic resonance (NMR) spectroscopy. The S. carteri MCE showed a promising result with a half-maximal inhibitory concentration (IC50) of 20.22 μg/mL in the preventive assay, while no IC50 was determined in the detachment assay since all inhibitions < 50%. The S. carteri MCE exhibited broad-spectrum antibacterial activity and displayed a non-cytotoxic effect. Fraction 4 from MCE of S. carteri (IC50 = 2.40 μg/mL) reduced the biofilm in the preventive assay at all concentrations and exhibited no antibacterial activity indicating the independence of antibiofilm from antibacterial properties. Based on the data obtained, an alkaloid named debromohymenialdisine (DBH) was identified from Fraction 4 of S. carteri MCE. In conclusion, S. carteri was able to reduce the establishment of the biofilm formed by P. aeruginosa and could serve as a prominent source of natural antifouling agents.
... Several researchers reported that polar and non-polar extracts from brown algae, including Sargassum vulgare, Padina sp., S. furcatum, and Dictyota sp., and red algae, such as Asparagopsis taxiformis, Pterocladiella capillacea, Spyridia aculeate, and Peyssonnelia capensis, exhibited anti-QS activity (Dahms and Dobretsov, 2017). It has also been reported that different extracts from seaweeds such as U. reticulate, Sargassum wightii, Halimeda macroloba, and sea grasses, such as Halodule pinifolia and Cymodocea serrulata, exhibited anti-biofilm formation activity against Pseudomonas, Flavobacterium, Bacillus, and Cytophaga species. ...
... Furthermore, the green Ulva lactuca extract was considered as a renewable source of new active anti-biofilm agents. Investigation reported that the polar and non-polar extracts of green seaweeds such as Caulerpa racemose, Codium spp., and Ulva (Enteromorpha) fasciata had anti-QS activity (Dahms and Dobretsov, 2017). Rima and Trognon (Rima et al., 2022) explored the biofilm formation inhibition activity of extracts from various macroalgae, including green alga U. lactuca, brown alga Stypocaulon scoparium, and red alga Pterocladiella capillacea toward P. aeruginosa. ...
A large number of microbial species tend to communicate and produce biofilm which causes numerous microbial infections, antibiotic resistance, and economic problems across different industries. Therefore, advanced anti-biofilms are required with novel attributes and targets, such as quorum sensing communication system. Meanwhile, quorum sensing inhibitors as promising anti-biofilm molecules result in the inhibition of particular phenotype expression blocking of cell-to-cell communication, which would be more acceptable than conventional strategies. Many natural products are identified as anti-biofilm agents from different plants, microorganisms, and marine extracts. Marine algae are promising sources of broadly novel compounds with anti-biofilm activity. Algae extracts and their metabolites such as sulfated polysaccharides (fucoidan), carotenoids (zeaxanthin and lutein), lipid and fatty acids (γ-linolenic acid and linoleic acid), and phlorotannins can inhibit the cell attachment, reduce the cell growth, interfere in quorum sensing pathway by blocking related enzymes, and disrupt extracellular polymeric substances. In this review, the mechanisms of biofilm formation, quorum sensing pathway, and recently identified marine algae natural products as anti-biofilm agents will be discussed.
... It is well known that a biomass hydrophilic layer on the surface of kelp can largely reduce the frictional resistance at solid/liquid interfaces (Dahms and Dobretsov 2017). Thus, the construction of a hydrophilic lubrication interface is a green bionic means for improving the friction properties of solid surfaces (Fang et al. 2019). ...
Lyocell fibers are currently claimed as green fibers with good application prospects, but the major problem of fibrillation restricts further promotion and application. In this study, based on the theory of hydration lubrication at the solid/liquid interface, hexamethylene-diisocyanate trimer (HDIt), polyethylene glycol (PEG), and butanone oxime (MEKO) were used to synthesize a reactive hydrophilic triblock polyurethane (RHT-PU). RHT-PU could construct a water lubrication layer on the lyocell fiber surface via H-bonding between polyoxyethylene ether and water molecules, reducing the coefficient of friction (CoF) of the fiber interface in the water. It was found that PEG molecular weight and grafting density had significant effects on the CoF of modified fabrics, with CoFs decreased with increased PEG molecular weight and grafting density. In water, the CoFs of fabrics modified by RHT-PU were reduced from 0.45 to 0.32 and maintained lower CoFs at higher temperature and higher normal loads. After mechanical friction and household washing tests, the surface abrasion of modified fabrics were significantly improved and color fading grade of fabrics raised from 3 grade to 4–5 grade. Construction of water-lubricated interfaces effectively reduced fibrillation.
... Consequently, the search for environment friendly antifouling agents that can effectively control biofouling without affecting non-target organisms has been triggered across the world (Raveendran and LimnaMol 2009). Natural product research revealed that the metabolites obtained from natural sources have biodegradable and effective antifouling properties; therefore they can be used as effective alternatives in antifouling paints to replace toxic biocides (Qian et al. 2010;Dahms and Dobretsov 2017). Among them, the compounds produced by marine organisms have vital role due to their novelty and effective bioactive properties (You et al. 2007;Dheilly et al. 2010;Salama et al. 2017). ...
The bacteria associated with marine invertebrates are considered as a potential source of biologically active compounds. In the present study, the bacterium Vibrio alginolyticus obtained from the shell surface of the marine gastropod Turbo intercostalis displayed strong antibacterial activity in the preliminary screening against biofilm-forming bacteria. Further antibiofilm assay exhibited that the extract of V. alginolyticus substantially inhibited the biofilm forming ability of Alteromonas sp. Moreover, the extract of V. alginolyticus showed significant antifouling activity against the marine biofouling organisms in the field study conducted in the coastal waters. In addition, the active components of the extract were eluted by chromatography methods and analysed using gas chromatography and mass spectroscopy (GC-MS). The obtained GC-MS spectrum indicated the presence of the compounds such as 1H-Indole, 5-methyl-2-phenyl, 2-Ethylacridine and diethyl bis (trimethylsilyl) silicate. The in silico analysis of the identified compounds was carried out against the molecular target barnacle cement protein. The compound 2-Ethylacridine showed promising activity than the other compounds including the reference antifouling agent 5-Dichloro-2-n-octyl-4-isothiazolin-3-one. In conclusion, results of this study indicated the antibiofilm and antifouling activities of the compounds produced by the bacterium V. alginolyticus. These compounds could serve as potential leads for the development of natural product-based antifouling agents.
... It is well known that a biomass hydrophilic layer on the surface of kelp can largely reduce the frictional resistance at solid/liquid interfaces (Dahms and Dobretsov 2017). Thus, the construction of a hydrophilic lubrication interface is a green bionic means for improving the friction properties of solid surfaces (Fang et al. 2019). ...
Lyocell fibers are currently claimed as green fiber with a good application prospect, but the major problem of fibrillation restricts the further promotion and application. In this study, based on the theory of hydration lubrication at the solid/liquid interface, hexamethylene-diisocyanate trimer (HDIt), polyethylene glycol (PEG), and butanone oxime (MEKO) were used to synthesize a reactive hydrophilic triblock polyurethane (RHT-PU). RHT-PU could construct a water lubrication layer on the lyocell fiber surface via hydrogen bonding between polyoxyethylene ether and water molecular, reducing the coefficient of friction (COF) of the fiber interface in the water. It was found that PEG molecular weight and grafting density had significant dependence on the COF of modified fabrics, COFs decreased with the increase of PEG molecular weight and grafting density. In water, the COFs of fabrics modified by RHT-PU were reduced from 0.45 to 0.32 and maintained lower COF at higher temperature and higher normal loads. After mechanical friction and household washing test, the surface abrasion of modified fabrics were significantly improved, and color fading grade of fabrics raised from 3 grade to 4–5 grade. Construction of water lubricated interfaces effectively reduced the fibrillation.
... These compounds play a vital role in the ecological relationships of organisms with their hosts (Abd-Ellatif et al., 2019). Marine macroalgae, seaweeds, or seagrasses are rich sources of numerous substances with numerous biological impacts, including antioxidant (Ramah et al., 2014), antibacterial (Chandrasekaran et al., 2014), anticancer (Pradhan et al., 2020), anti-inflammatory (Dahms & Dobretsov, 2017), anti-viral (Besednova et al., 2021), antiinfluenza (Besednova et al., 2021), and anti-COVID-19 (Rahman et al., 2022) activities. Marine organisms are the source of hundreds of novel compounds discovered every year. ...
The epidermal growth factor receptor (EGFR) dimerizes upon ligand bindings to the extracellular domain that initiates the downstream signaling cascades and activates intracellular kinase domain. Thus, activation of autophosphorylation through kinase domain results in metastasis, cell proliferation, and angiogenesis. The main objective of this research is to discover more promising anti-cancer lead compound against EGRF from the phenolic acids of marine natural products using in-silico approaches.
Phenolic compounds reported from marine sources are reviewed from previous literatures. Furthermore, molecular docking was carried out using the online tool CB-Dock. The molecules with good docking and binding energies scores were subjected to ADME, toxicity and drug-likeness analysis. Subsequently, molecules from the docking experiments were also evaluated using the acute toxicity and MD simulation studies. Fourteen phenolic compounds from the reported literatures were
reviewed based on the findings, isolation, characterized and applications. Molecular docking studies proved that the phenolic acids have good binding fitting by forming hydrogen bonds with amino acid residues at the binding site of EGFR. Chlorogenic acid, Chicoric acid and Rosmarinic acid showed the best binding energies score and forming hydrogen bonds with amino acid residues compare to the reference drug Erlotinib. Among these compounds, Rosmarinic acid showed the good pharmacokinetics profiles as well as acute toxicity profile. The MD simulation study further revealed that the lead complex is stable and could be future drug to treat the cancer disease. Furthermore, in a wet lab environment, both in-vitro and in-vivo testing will be employed to validate the existing computational results.
... Basic research started with marine sessile organisms which are keeping their surfaces free from fouling organisms by producing secondary metabolites. The identified secondary metabolites from many microorganisms showed antifouling activity [12]. It is one of the strategies to prevent biofouling by hydrolyzing adhesives of fouling organisms using enzymes Proteases are the key antifouling active components in enzyme-based antifouling coatings. ...
Biofouling is the result of a biological process that is the accumulation of micro- and macro-organisms on the surfaces of the ship which causes serious environmental problems. The consequence of biofouling includes modifying the hydrodynamic response, affecting heat exchange, can make structures heavier, accelerate or generating corrosion, biodegradation, increasing the fatigue of certain materials, and blocking mechanical functions. It causes severe problems for the objects in the water such as ships and buoys. Also, its impact on shellfish and other aquaculture was sometimes devastating. The main scope of this study is to review the currently available biocides from biological agents for marine submerged foulants and marine foulers that are present around the coastal areas of Tamil Nadu. Biological anti-fouling methods are preferred than that of the chemical and physical anti-fouling methods as it have some toxic effects on the non targeted marine biodiversity. This study focuses on the marine foulers that are present around the coastal areas of Tamil Nadu which will be helpful for the researchers to discover the suitable anti-foulers from a biological source, which will be very useful to protect the marine ecosystem and marine economy. A total of 182 antifouling compounds from marine biological sources were discovered. The marine microbes, Penicillium sp. and Pseudoalteromonas issachenkonii, were reported to possess EC50. The survey results obtained from this study show that Chennai coastal region has a lot of barnacles, and 8 different species were present in Pondicherry region.
... Humans are also exposed to severe health risks after ingestion of contaminated fish and shellfish. 14 When shipyard workers are exposed to TBT dust and vapors, organs such as the liver and kidney are primarily affected. At the same time, minor symptoms such as skin irritation, breathing problems, dizziness, cold, and flu are also reported. ...
Biofouling is a serious concern and can cause health risks and financial burdens in many settings such as maritime structures, medical devices, and water treatment plants. Many technologies employing toxic biocides, antifouling toxic coatings, and chlorine have been established to prevent or impede biofouling. However, their applications are limited due to environmental and health concerns regarding biocides and coating materials. To overcome this, novel antifouling coatings employing eco-friendly, nontoxic nanomaterials and appreciable antimicrobial and antibiofilm properties have been developed. Due to intrinsic antimicrobial properties, these antifouling nanocoatings have been proven to be effective against several water-borne microorganisms. Various nanostructures of metals (silver, copper, and gold), metal oxides (zinc oxide, titanium oxide, copper oxide, and cerium oxide), carbon (graphene and carbon nanotubes), and metal nanocomposites inhibit the biocorrosion and biofilm formation caused by bacteria. Besides, antifouling technology developed based on nanocontainers releases key active substances that promote self-cleaning, anticorrosion, and anti-biofilm properties. This review provides a comprehensive overview of nanotechnology-enabled antifouling agents developed to combat micro-and macrofouling phenomena. Moreover, the recent progress in using antifouling coatings in industrial sectors such as marine (ships), water-treatment plants, and medical devices is elaborated on with examples. The mechanistic insights into the inhibitory action of bacterial cell growth and biofilm formation by antifouling nanocoatings are presented. The challenges associated with developing antifouling nanoproducts, their practical limitations and prospects are also discussed.
