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Non-communicable diseases (NCD) are the leading cause of death and disability worldwide. The four main leading causes of NCD are cardiovascular diseases, cancers, respiratory diseases and diabetes. Recognizing the devastating impact of NCD, novel prevention and treatment strategies are extensively sought. Marine organisms are considered as an impor...
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... isolated peptide could inhibit VEGF induced migration and tubulogenesis of human umbilical vein endothelial cells (HUVECs) [81]. As summarized in Table 2, anti-cancer peptides from other marine fish such as pipefish, Red Sea Moses sole, tuna, anchovy and grouper have also been isolated and purified [82][83][84][85][86]. The peptides isolated from marine fish showed anti-cancer activity in human breast cancer (MCF-7), human lung carcinoma (A549), human leukemic lymphoblasts (CCRF-CEM), hepatocellular carcinoma (HA59T/VGH), cervical cancer [87], human liver cancer (HepG2), human fibrosarcoma (HT1080), human myeloid leukemia (U937), human prostate cancer (PC-3), and oral squamous cell carcinoma (OSCC) cells. ...Context 2
... cells treated with pardaxin also showed elevation of caspase-3/7 activities, disruption of the mitochondrial membrane potential, and accumulation of reactive oxygen species (ROS) production [89]. However, compared to the snake-derived venom peptide; IC 50 value of anti-cancer effects of marine-derived bioactive peptides is relatively higher (Table 2). ...Context 3
... was estimated that in high-risk populations, consumption of 40-60 g fish per day leads to 50% reduction in death from NCD (i.e., CVD, and cancer) [97]. Supporting those epidemiological studies, anti-cancer effects of fish-derived bioactive peptides in several cell lines also has been reported (Table 2). Unfortunately, fish consumption is very low even in some countries known for their large fish stock, such as in the north African region; hence, nutraceuticals derived from fish peptide can be develop in order to alleviate NCD. ...Citations
... In clinical treatment, radiotherapy and chemotherapy often have severe side effects [4], seriously affecting the physical and mental health of patients [5]. Given that cancer stands as a prevalent cause of death and disability worldwide [6], it is imperative to explore alternative approaches for both prevention and treatment of this devastating ailment. ...
... One reason is proximity to existing seaweed-related development. Indonesia is the top seaweed-producing country (FAO 2020), and South Sulawesi is the leading Indonesian province in the field of seaweed farming (mariculture and brackish-water pond culture), both in terms of local production and as a regional hub for seaweed farming, trade and processing industries (Nuryartono et al. 2021;Langford et al. 2022), as shown in Fig. 26.1. Furthermore, UNHAS researchers have a track record in seaweed-related research as well as in bringing seaweed knowledge and advances to the wider community through a variety of outreach mechanisms. ...
... The CEDUS-UNHAS emerged from a process lasting over 20 years (Fig. 26.2). In the early 1990s, UNHAS seaweed researchers pioneered seaweed farming in the coastal waters of South Sulawesi, especially in the Takalar The Consortium activities helped to strengthen the position of South Sulawesi as a major seaweed farming centre, producing approximately 3.67 tons/year, contributing 30-35% of Indonesian and approximately 11% of global seaweed production volume, including over 20% of the global supply of carrageenan seaweeds (Nuryartono et al. 2021 ...
... Sanapala et al. [138] highlights the importance of improving and refining extraction methods, to obtain BP in their natural forms as far as possible to increase utility value. Fish protein hydrolysates having known amino acid sequences, with potential to generate high value nutraceuticals and healthcare products industrially, are useful in gaining consumer acceptance and for treating several non-communicable diseases [139]. The potential to utilize hydrolysates for the benefit of human health, justifies development of processes, to generate purpose-oriented products 16 from low-cost raw materials from fish waste. ...
Global marine fish harvest has reached a plateau over the last decade. Efforts to increase aquaculture tend to face limitations in water resources and contamination problems. Of the current fish harvest at least 50% is discarded as waste. The chemical and microbiological contaminations limit the utilization of harvested fish. There is a need to improve fish preservation to minimize spoilage and process them into more appealing products. Instead of resorting to individual food processing methods, the efficiency of processing could best be increased by a combination of conventional and modern processing methods, or combinations of modern processing methods. Fish waste is a rich source of oils containing essential fatty acids, polypeptides, and amino polysaccharides that could be utilized through upscaling of the current scientifically proven methods, to new processing technologies. Separation of collagens, gelatins, bioactive peptides, edible fish oils, and chitosan form the primary stages in the utilization of fish waste. The products need purification to meet food quality and safety standards, and desirable industrial characteristics. The diversity of information and products generated through new methods requires advanced data handling and prediction systems, such as artificial intelligence, to address food safety and get the best out of fish processing and utilization.
... (EC) No. 1069/2009European Commission, 2009] which prevents the feeding of F&A byproducts to the same aquaculture species (Gasco et al., 2020). Many studies on the extraction of valuable bioactive chemicals of pharmaceutical, nutraceutical, and cosmeceutical importance have been reported (Najafian & Babji, 2012;Ahn et al., 2015;Chi et al., 2015;Nurdiani et al., 2017;Pangestuti & Kim, 2017). Therefore, the growing interest of several companies in F&A by-products for the isolation of anti-inflammatory, immunomodulatory, antimicrobial, antiviral, anti-carcinogenic, antioxidant, and cardioprotective substances (Cheung et al., 2015;Shabani et al., 2018;Bruno et al., 2019) may constitute competitive interest against their use in aquafeed. ...
With aquaculture intensifying to meet future demands and forage
fish stocks nearing their ecological limits, fed aquaculture must
continue to scale down reliance on fishmeal and fish oil to safeguard
the sustainable development of the sector. Sustainable alternative
feed ingredients for the production of aquafeeds are paramount.
Apart from terrestrial plant-based and animal-based ingredients,
fishery and aquaculture by-products and insects are presently the
most viable alternative sources.
... Dietary supplements based on hydrolysates of fish scales and skin are recommended for use in formulations of specialized functional nutrition products [2]. Given the high collagen content, hydrolysates can be used to correct metabolic disorders in the synthesis and regeneration of collagen tissues in the body [46][47][48][49][50][51]. The antioxidant activity of the obtained hydrolysates was established in the work. ...
Experimental studies of fish cutting waste—scales and skin were carried out, their general biochemical composition was studied, a high content of collagen was established, and elastin was noted, which accounted for 76–86% of the protein mass. Processes for the hydrolysis of secondary fish raw materials have been developed: fish scales and skin. Technological schemes have been developed and the influence of the conditions of thermal, enzymatic, enzymatic-thermal, electrochemical hydrolysis on the amino acid composition and molecular weight distribution (MWD) and antioxidant activity of peptides and proteins in the obtained hydrolysates has been studied. It has been established that the enzymatic and enzymatic-thermal method of hydrolysis of fish scales using the enzyme Alcalase 2.5 L and the electrochemical hydrolysis of the skin of cod, trout and herring made it possible to obtain protein hydrolysates with a protein content of 80–90%. At the same time, 91–98% of enzymatic hydrolysates from scales and 62%, 74% and 82.5% of electrochemically obtained hydrolysates from the skin of trout, herring, cod, respectively, account for the share of low-molecular peptides with a molecular weight of less than 10 kDa. The prospects of their use in functional foods and oil-containing products are noted.
... Discodermins, halicylindramides A-C, jaspamide, and Geodiomolides A, B, H, and I are some of the marine sponge-derived peptides that aid in the treatment of cancer in patients. Similarly, various peptides such as Neovastat, pardaxin, PAB 1 and 2, PG155, Syngnathusin, Epinecidin-1, etc. are extracted from fish species having functional compounds that help in cancer treatment (Pangestuti and Kim 2017). Seaweed peptides have a bioactive potential that prevents diabetes. ...
One of the most critical uses in the food business is the encapsulation of food components. Bioactive components are being used in food applications due to growing consumer interest in natural ingredients. Encapsulation is a promising method for improving the stability of bioactive components while allowing for regulated release. This chapter presents an overview of various encapsulation procedures, viz. spray drying, freeze-drying, extrusion, emulsification, coacervation, cocrystallisation, supercritical fluid method, and different encapsulated bioactive compounds, which have been used to fortify food components and deliver them into various functional foods.
... Discodermins, halicylindramides A-C, jaspamide, and Geodiomolides A, B, H, and I are some of the marine sponge-derived peptides that aid in the treatment of cancer in patients. Similarly, various peptides such as Neovastat, pardaxin, PAB 1 and 2, PG155, Syngnathusin, Epinecidin-1, etc. are extracted from fish species having functional compounds that help in cancer treatment (Pangestuti and Kim 2017). Seaweed peptides have a bioactive potential that prevents diabetes. ...
Natural bioactive compounds are molecules’ treasure trove for nutraceuticals, food additives, and functional foods, as they exhibit several structures and activities. Some of these chemicals, such as polyphenols, can be found in high concentrations in nature. However, others are present in such low concentrations that significant harvesting is vital to achieving sufficient quantities, and chemical synthesis is unprofitable due to their structural diversity and complexity. Because screening and synthesizing these compounds are complex, new technologies have been created. The most common approach is traditional liquid or solid–liquid extraction also termed solvent extraction, although modern approaches comprise supercritical and subcritical extractions, pressured liquid extraction, along with microwave and ultrasound-assisted extractions. Such technologies could give a novel technique for increasing the construction of bioactive and usage of such particular compounds as nutraceuticals or as ingredients in functional foods.KeywordsPressured liquid extractionBioactive componentsSolid–liquid extractionFunctional potential
... Nowadays, many studies have been conducted to produce bioactive peptides from the hydrolyzed protein of marine organisms to produce a high value-added product [5,6]. In addition to functional and nutritional properties, these bioactive peptides have broad therapeutic effects [7][8][9]. ...
This study aimed to evaluate the physicochemical, structural, antioxidant, and antibacterial properties of chitosan-coated (0.5 and 1% CH) nanoliposomes containing hydrolyzed protein of Spirulina platensis and its stability in simulated gastric and intestine fluids. The chitosan coating of nanoliposomes containing Spirulina platensis hydrolyzed proteins increased their size and zeta potential. The Fourier transform infrared spectroscopy (FT-IR) test showed an effective interaction between the hydrolyzed protein, the nanoliposome, and the chitosan coating. Increasing the concentration of hydrolyzed protein and the percentage of chitosan coating neutralized the decreasing effect of microencapsulation on the antioxidant activity of peptides. Chitosan coating (1%) resulted in improved stability of size, zeta potential, and polydispersity index (PDI) of nanoliposomes, and lowered the release of the hydrolyzed Spirulina platensis protein from nanoliposomes. Increasing the percentage of chitosan coating neutralized the decrease in the antibacterial properties of nanoliposomes containing hydrolyzed proteins. This study showed that 1% chitosan-coated nanoliposomes can protect Spirulina platensis hydrolyzed proteins and maintain their antioxidant and antibacterial activities.
... The use of those nutrient-rich materials is essential for improving economic efficiency and environmental protection (Nawaz et al., 2020;Stevens et al., 2018). Fresh (i.e., low oxidative deterioration and off-odor) BPs are sources of proteins for fish protein hydrolysates (FPHs) as functional food ingredients with various biological activities (e.g., antioxidant, anticancer, anti-diabetic, antihypertensive, anti-obesity, and immunomodulatory activities; Hamed et al., 2015;Iwaniak et al., 2014;Nikoo et al., 2014;Olsen et al., 2014;Ozogul et al., 2021;Pangestuti & Kim, 2017;Phadke et al., 2021;Sarteshnizi et al., 2021;Šimat, 2021;Singh et al., 2021;Ucak et al., 2021;Zhang et al., 2021). The bioactivities depend on the structure of bioactive peptides (BAPs), including amino acid composition, sequence, size, hydrophobicity, charge, and conformation (Bhandari et al., 2020;Le Gouic et al., 2019;Udenigwe & Fogliano, 2017;Xue et al., 2021). ...
Autolysis technology has shown potential for protein hydrolysates production from marine and aquaculture byproducts. Viscera are a source of cheap proteolytic enzymes for producing protein hydrolysates from the whole fish or processing byproducts of the most valuable commercial species by applying autolysis technology. The use of autolysis allows economical production of protein hydrolysate and provides an opportunity to valorize downstream fish and shellfish processing byproducts at a lower cost. As a result, production and application of marine byproduct autolysates is increasing in the global protein hydrolysates market. Nevertheless, several restrictions occur with autolysis, including lipid and protein oxidation mediated by the heterogeneous composition of byproducts. The generally poor storage and handling of byproducts may increase the formation of undesirable metabolites during autolysis, which can be harmful. The formation of nitrogenous compounds (i.e., biogenic amines), loss of freshness, and process of autolysis in the byproducts could increase the rate of quality and safety loss and lead to more significant concern about the use of autolysates for human food applications. The current review focuses on the autolysis process, which is applied for the hydrolysis of aquaculture and marine discards to obtain peptides as functional or nutritive ingredients. It further addresses the latest findings on the mechanisms and factors contributing the deterioration of byproducts and possible ways to control oxidation and other food quality and safety issues in raw materials and protein hydrolysates.
... Synthetic analogs of porphyran may be more bioavailable if they are synthesized and tested. Porphyran and its synthetic equivalents may benefit from using nano-carriers, micro-emulsions, liposomes, polymers, and micelles to improve bioavailability and target specificity (Pangestuti & Kim, 2017). In addition, these methods will improve their solubility and metabolism in host systems. ...
... In addition, these methods will improve their solubility and metabolism in host systems. Furthermore, the target specificity of apoptosis and autophagy will improve their preclinical and clinical efficacy (Pangestuti & Kim, 2017). Porphyran, combined with FDAapproved medications, may offer a lot of promise for improving clinical effectiveness (Karthikeyan et al., 2022;Pradhan et al., 2022d). ...
Seaweeds are high in bioactive chemicals frequently used to treat human illnesses. Porphyran is a polysaccharide found in the red seaweeds of the genus Porphyra. Porphyran has been discovered to have immunomodulatory, anti-inflammatory activity, and anti-cancer effects via boosting immunity and targeting important apoptotic molecules, making them potential chemotherapeutic or chemopreventive drugs. Polysaccharide-mediated dynamic control of apoptosis and autophagy in cancer has been a viable treatment with low cytotoxicity with high efficacy. Thus, comprehending the influence of porphyran on human health and their molecular mechanisms would open up a new paradigm in cancer therapies. Also, the importance of apoptotic/autophagy modulating porphyran in cancer therapy has been highlighted as the future direction of improved nano-formulation for improved clinical efficacy. This review focuses on the current research into porphyran's anti-cancer efficacy and putative mechanisms of action through apoptosis and autophagy in various cancers, as well as its potential chemotherapeutic treatment in near future.
