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Antenatal management of fetal cerebral ventriculomegaly. 

Antenatal management of fetal cerebral ventriculomegaly. 

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Article
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Ventriculomegaly is an increase in cerebral ventricular dimensions. It could be secondary to increased cerebrospinal fluid pressure in the ventricular cavity (hydrocephalus), or to a lack of brain parenchyma due to atrophic involution or arrested development. Ventriculomegaly causes diagnostic, therapeutic, and prognostic dilemma for obstetricians,...

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Context 1
... diagnosis of X-linked HCP spectrum could be done by the presence of adducted thumbs in combi- nation with VM and other intracranial abnormalities. A flowchart for management of fetal cerebral VM is constructed (Fig. ...

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Citations

... Fetal intracranial hemorrhage (ICH) is a major risk for hydrocephalus (posthemorrhagic hydrocephalus, PHH)[131,142,143]. PHH is a common neurological disorder characterized by increased head size, cortical thinning, ventricular cerebrospinal fluid accumulation, and ventriculomegaly. ...
Chapter
LPA is a bioactive phospholipid with a plethora of roles in the developing and adult nervous system. LPA signaling mediates many processes in the brain including survival, development and function of neural progenitor cells, astrocytes, oligodendrocytes, and microglia. The intricate spatiotemporal pattern of LPA metabolism and receptor expression are critical for normal CNS development; altered LPA signaling underlies fetal lethality, neurodevelopmental deficits, and is associated with neuropsychiatric impairments and cognitive decline. Fetal hypoxic and hemorrhagic injuries are major causes for neurodevelopmental defects and these injury mechanisms are linked to changes in LPA signaling during critical periods of corticogenesis. This chapter will focus on the role of LPA in neurogenesis of the developing brain and the contribution of aberrant LPA signaling and metabolism in the pathogenesis of neurodevelopmental diseases.