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Angiographic images of the right internal carotid artery (ICA) on the anteroposterior and lateral views revealed segmental occlusion of the posterior division of the right middle cerebral artery (M2 segment). Distal occlusion of the few of cortical branches of the right anterior cerebral artery (ACA) was also observed (black arrows).
Source publication
Patient: Male, 71-year-old
Final Diagnosis: Stroke
Symptoms: Hemiplegia
Medication: —
Clinical Procedure: —
Specialty: Rehabilitation
Objective
Unusual or unexpected effect of treatment
Background
The criterion standard treatments for ischemic stroke patients, starting from systemic thrombolysis and/or undergoing endovascular recanalization thera...
Context in source publication
Context 1
... post-thrombectomy angiogram showed recanalization of right proximal MCA and branches with a Thrombolysis in Cerebral Infarction (TICI) score of 3. No immediate complications were noted. The pre-and post-thrombectomy angiogram images of the right ICA are shown in Figures 1 and 2. An immediate post-thrombectomy CT brain showed a small hypodense hyperacute infarction at the right paracentral lobule, right preand post-central gyri, and right insular lobe. ...
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Importance:
It is estimated that only 27% of patients with acute ischemic stroke and large vessel occlusion who undergo successful reperfusion after mechanical thrombectomy are disability free at 90 days. An incomplete microcirculatory reperfusion might contribute to these suboptimal clinical benefits.
Objective:
To investigate whether treatment...
Citations
... The understanding of the physio-pathological processes can lead to new treatment strategies. Because of the promising results of some neuroprotective treatments in the experimental setup [24,26] and clinical practice [25,49], we investigated if this kind of treatment could also help protect patients suffering from liver damage. Although the treatment did not yield a huge behavior change, with both treated and untreated groups being less mobile (Figure 3d,e) compared to sham and no apparent short-term memory benefit being observed (Figure 3g), we did see some cellular benefits to the treatment. ...
Liver damage can lead to secondary organ damage by toxic substances and catabolic products accumulation which can increase the permeability of blood-brain barrier, leading to cognitive impairment. The only real treatment for end stage liver failure is grafting. With some, but not all, neurological symptoms subsiding after transplantation, the presence of brain damage can impair both the short and long-term outcome. We tested if Cerebrolysin can prevent brain injury in an experimental model of non-viral liver damage in mice. Behavior, abdominal ultrasound evaluation and immunohistochemistry were used to evaluate the animals. No ultrasound or behavior differences were found between the control and treated animals, with both groups displaying more anxiety and no short-term memory benefit compared to sham mice. Cerebrolysin treatment was able to maintain a normal level of cortical NeuN+ cells and induced an increase in the area occupied by BrdU+ cells. Surprisingly, no difference was observed when investigating Iba1+ cells. With neurological complications of end-stage liver disease impacting the rehabilitation of patients receiving liver grafts, a neuroprotective treatment of patients on the waiting lists might improve their rehabilitation outcome by ensuring a minimal cerebral damage.
