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Analysis of DNA from cells of basal cell carcinoma of low and high risk by flow cytometry. Results were expressed as mean percentage of cells in different phases of the cell cycle: G2M, synthesis S, G0/G1, apoptosis and cellular debris. *Significant difference with P < 0.001 ANOVA test.
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Basal cell carcinoma (BCC) is the most common skin malignancy, are found in various forms depending on their clinical and biological behavior. The objective of study was analyzed the phases of the cell cycle and correlations between BCC of low and high risk of re-currence and correlation prognostic factors. The qu-antity of content DNA in tissues o...
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... BCC 6.4%), G0/G1 (normal skin-50.3% and BCC 11.1%) and apoptosis (normal skin 0.29% and BCC 7.8%). Sta- tistical analysis enhanced show the population in chan- ges contends of DNA, aneuploids (normal skin 0.01% and 3.1% BCC) and cellular debris/necrosis (normal skin 33.3% and BCC 60.9%) (Figure 2). ...
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Citations
... Basal cell carcinoma (BCC) is the most common clinical skin malignancy and neoplasm, [1][2][3][4][5][6][7] amounting to approximately 500 cases per 100,000 population. The lifetime risk of contracting BCC is approximately 30%. ...
We investigated radiosensitization in an untreated basal cell carcinoma (TE.354.T) cell line and post-pretreatment with tetraiodothyroacetic acid (tetrac) X 1 h at 37°C, 0.2 and 2.0 µM tetrac. Radioresistant TE.354.T cells were grown in modified medium containing fibroblast growth factor-2, stem cell factor-1 and a reduced calcium level. We also added reproductively inactivated (30 Gy) “feeder cells” to the medium. The in vitro doubling time was 34.1 h, and the colony forming efficiency was 5.09 percent. These results were therefore suitable for clonogenic radiation survival assessment. The 250 kVp x-ray survival curve of control TE.354.T cells showed linear-quadratic survival parameters of αx-ray = 0.201 Gy⁻¹ and βx-ray = 0.125 Gy⁻². Tetrac concentrations of either 0.2 or 2.0 µM produced αx-ray and βx-ray parameters of 2.010 and 0.282 Gy⁻¹ and 2.050 and 0.837 Gy⁻², respectively. The surviving fraction at 2 Gy (SF2) for control cells was 0.581, while values for 0.2 and 2.0 µM tetrac were 0.281 and 0.024. The SF2 data show that tetrac concentrations of 0.2 and 2.0 µM sensitize otherwise radioresistant TE.354.T cells by factors of 2.1 and 24.0, respectively. Thus, radioresistant basal cell carcinoma cells may be radiosensitized pharmacologically by exposure to tetrac.
This paper investigates the use of computerized fractal analysis for objective characterization of the complexity of the epithelial-connective tissue interface in basal cell carcinoma and the ability of the technique to quantitatively discriminate among different diagnostic categories. Tumor boundaries were extracted by means of image analysis. The fractal dimension was calculated by using the box-counting method. The results showed that the shape of the boundaries between epithelium and stroma is significantly more complex in infiltrative high risk tumors than in circumscribed low risk ones (p<0.001), with 100% correct classifications. This study shows that the computerized fractal analysis of epithelial-connective tissue interface in basal cell carcinomas can provide an accurate, quantitative, inexpensive technique to help in tumor diagnosis.
