Figure - available from: Frontiers in Cell and Developmental Biology
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Alternative splicing analysis of CHMP7. (A) The read-in, read-out, and PSI values of CHMP7 _alt_5prime in tumor and normal tissues. (B) Differences in PSI value between tumor and adjacent normal tissue (top), and tumor and GTEx normal tissue (bottom); red dashed line refers to FDR of 0.05. (C) Kaplan-Meier curves present the effect of PSI values of CHMP7 _alt_5prime on patient OS, DSS, DFI, and PFI. (D) Isoform switch events of the CHMP7 gene in pan-cancer.
Source publication
Introduction: ESCRT is a molecular machine involved in various important physiological processes, such as the formation of multivesicular bodies, cellular autophagy, and cellular membrane repair. CHMP7 is a regulatory subunit of ESCRT-III and is necessary for the proper functioning of ESCRT. In this study, public databases were exploited to explore...
