Fig 1 - uploaded by ElSagad Eltayeb Gady
Content may be subject to copyright.
Source publication
p> Background: Cancer is an increasingly important public health problem in developing countries, including Sudan. The burden of colorectal cancer in Sudan is unknown, mainly because of lack of statistics or under reporting. Colorectal carcinoma is the most common malignancy of the GI tract, unfortunately there are few statistical data regarding co...
Context in source publication
Context 1
... total of 63 patients included. The mean age of the patients in this study was 50.5 (±11.7), ( Fig. 1) range between (18 -75 years), the total number of patients below 48 years was 40% (n= 25). Male to female ratio was appriximately1:1. Geographic distribution showed that most of the patients presented from Khartoum state 33.3% (n=21), followed by northern state &Kurdufan state 14.3% (n=9) each, then Darfur state 11% (n=7). The median ...
Similar publications
A Korteweg-de Vries (KdV) equation including the effect of Landau damping is derived to study the propagation of weakly nonlinear and weakly dispersive ion acoustic waves in a collisionless unmagnetized plasma consisting of warm adiabatic ions and two different species of electrons at different temperatures. The hotter energetic electron species fo...
Amfibi hava araçları, konvansiyonel hava araçlarının maruz kaldığı aerodinamik etkilerin yanı sıra, sudan kalkış ve suya iniş koşullarında hidrodinamik etkilere maruz kalmakta, bu sebeple geometrileri hem aerodinamik hem de hidrodinamik etkiler göz önüne alınarak eniyilenmektedir. Çalışmada, hidrodinamik sürükleme kuvvetini azaltmak için gereken ba...
Assessment of hydrometer against standard pipette methods for particle size measurements has been investigated
in twenty-six soil samples collected from different climatological and ecological regions in central Sudan. Soil
particle size distribution was determined using the two different methods in an attempt to insure that if the
hydrometer metho...
Citations
... Numerous health and socioeconomic factors are implicated in the development of early-onset CRC (EORC) in Africa including a possible higher prevalence of LS among CRC African patients; however, additional studies are needed to validate such claims 20 . Similarly, EOCRC cases are reported in Sudan although it is hard to specifically describe the disease patterns based on the limited published reports 21,22 . The Table 3. OS and DFS of dMMR CRCs compared to pMMR CRCs. ...
Molecular pathology services for colorectal cancer (CRC) in Sudan represent a significant unmet clinical need. In a retrospective cohort study involving 50 patients diagnosed with CRC at three major medical settings in Sudan, we aimed to outline the introduction of a molecular genetic service for CRC in Sudan, and to explore the CRC molecular features and their relationship to patient survival and clinicopathological characteristics. Mismatch repair (MMR) and BRAF (V600E) mutation status were determined by immunohistochemistry. A mismatch repair deficient (dMMR) subtype was demonstrated in 16% of cases, and a presumptive Lynch Syndrome (LS) diagnosis was made in up to 14% of patients. dMMR CRC in Sudan is characterized by younger age at diagnosis and a higher incidence of right-sided tumours. We report a high mortality in Sudanese CRC patients, which correlates with advanced disease stage, and MMR status. Routine MMR immunohistochemistry (with sequential BRAF mutation analysis) is a feasible CRC prognostic and predictive molecular biomarker, as well as a screening tool for LS in low-middle-income countries (LMICs).
... Examples are Siegel et al in the USA and Gado in Egypt [8,9]. This trend has also been observed in Sudan in most of the studies done in Sudan over the past 2 decades [10][11][12][13][14]. With the exception of only one study [13], the mean age ranged from (50-54) years, and the percentages of colorectal cancer patients under the age of 50 years ranged from (34.5% -44%), and those below 30 years from (7-17%), (Table 4). ...
Objectives: Data on lower Gastrointestinal (GI) disease are generally sparse. In addition, the pattern of GI disease is changing over time. The objectives of this study were to identify the main indications and associated endoscopic findings in patients presenting for elective lower GI endoscopy at a major teaching hospital, thus provide database and identify the current pattern of lower GI disease in our community. Methods: This is a descriptive analytic study. We analyzed data collected prospectively over a period of 12 years (2007-2019). These included demographic data of patients, symptoms and endoscopic findings. Results: The study included 1086 patients. Diagnostic endoscopies (colonoscopy and sigmoidoscopy) were done for 989 patients (95.5%) and therapeutic procedures for 48 patients (4.5%). The most common symptoms were rec-tal bleeding (51.3%), followed by change in bowel habits (12.6%), abdominal pain (7.7%), perianal pain (6.7%) and anemia (4.1%). We further analyzed these symptoms regarding the endoscopic findings. Endoscopic findings showed prevalence of diseases once thought to be rare or non-existing. Colorectal tumors accounted for (10.1%) of the patients, most of which (80%) had rectal tumors and (34.5%) of these patients were below the age of 50. Conclusion: This study shows the current pattern of lower GI disease. There are trends of 'westernization' of disease and rectal cancers in younger patients than classically reported. These findings would have a strong socioeconomic impact on individual, society, and country as a whole. It provides important endoscopic database to policymakers, clinicians and researchers. It highlights the importance of endoscopy services, and focuses on areas needing further studies.
... Preoperative CEA was more than 2.5 in 110(88.7%) of the patients and less than 2.5 in 14 (11.3%). Comparable to Mohammed et al. [8] who reported that among Sudanese patients with colorectal cancer the CEA was found positive in 85.3%. In macroscopic appearance was ulcerative manifested in 60(48.4%), ...
... And Postoperative pathological staging showed figure near the imaging stage ,that stage B reported in 65(52.4%) of the patients, stage C 37(29.8%) stage A 9(7.3%) and stage D 8(6.5%). in five patients pathological staging was not reported. Unlike Mohammed et al. [8] showed that the 65% of the sample were advance tumor (Dukes stage C 46.7% and D 18.3). ...
... sigmoid colon 9(7.3%), ceacal 8(6.5%) and rectosigmoid 6(4.8%). This is similar to Mohammed et al. [8] found among patients Ibn Sina hospital left-side colonic carcinoma was 81% represented the majority of cases with rectosigmoid cancer account for 74% of all cases. In China Lee et al. [9] found that more frequently located in the left colon, had more micro satellite instability-high status, and showed more advanced stage than single cancer. ...
Background: Colorectal cancer is one of common cancers and second cause of death worldwide. In Sudan unfortunately there is few statistical date regarding colorectal cancer and its geographical, ethnic distribution, and pattern of presentation because of lack of statistics or underreporting. Objective: To study pattern of presentations and surgical outcome of colorectal cancer in Sudanese patients. Patients and methods: This study is descriptive cross sectional between (2014-2019); a prospective and retrospective study of histological confirmed cases of colorectal cancer was conducted at SUH. All patients who met the inclusion criteria were involved in the study. Results: We studied (124) patients in the period between (2014–2019). Highest percentage of the patients 78 (62.9%) aged between 46 – 70 years. The mean age was 67±2.4 years. Male to female ratio1.3:1. Rectal bleeding and altered bowel habits were the most frequent presenting symptoms. Left side colonic carcinoma was 82.7% represented the majority of cases with rectal tumor account for 49.2% of all cases. In preoperative, stage B was reported in majority of patients 74(59.7%). The most common surgical managements done for the patients were low anterior resection with or without ileostomy or colostomy32 (36.8%), APR 24(19.3%), left hemicolectomy 15(12.1%), right hemicolectomy 18(14.5%), sigmoid colectomy 9(7.3 and total colectomy 4(3.2%). Final histopathology reports showed that the 65% of the sample were moderately differentiated adenocarcinoma 76(61.3 %). the most frequent reported postoperative complication was surgical site infection 8(6.5%) and anastigmatic leak 3(2.4). Conclusion: The mean age of patients in this study was 67±2.4 year, with male to female ratio of 3:1. Rectal bleeding altered bowel habits were the most frequent presenting symptoms and anemia more common in right site. The most common endoscopy findings were rectal tumor, followed by anal tumor, sigmoid colon, ceacal and rectosigmoid. Anterior resection with or without ileostomy was the most frequent conducted operation. Surgical site infection was the most frequent complication followed by anastomotic leak. The final histopathology reports showed that majority of samples were advance ―Duke's stage C and D‖.
Keywords: colorectal cancer, PR bleeding.
... In Sudan, colorectal carcinoma is the most common malignancy of the Gastro-Intestinal tract.(4) And there is no statistical data regarding the geographical and racial distribution of the colonic tumors (5). ...
... Few studies was conducted and revealed that there is a different disease pattern in Sudan with high incidence rates tending to affect younger populations than those internationally reported. The rst presentation of the disease ranging from relatively healthy patient with few symptoms to life-threatening bowel obstruction with risk of perforation and fecal peritonitis (5). ...
Background Colorectal cancer is one of the most significant causes of cancer death. With records of high incidence and late detection of the disease in Sudan, and it was found to affect younger age groups.
Methods This study aimed to explore the incidence of colorectal lesions in the main endoscopic centers in Khartoum state- Sudan. It was a cross-sectional prospective study; data were collected from patients attending the main endoscopic centers in Sudan- Khartoum state during February 2013 to June 2014 including Khartoum teaching hospital, Neelain medical diagnostic center and Ibn sina hospital.
Results One hundred and six participants were diagnosed endoscopically with colorectal lesions, 44 (41.5%) showed inflammatory mucosa, 40 (37.7 %) showed tumor and 22 (20.7%) had polyps.
In the whole group of patients the mean age was 45.7 years, 34.2% of tumor patients were less than 50 years old, 46.8% of the lesions were in the rectum, the highest frequency of tumor patients group were from western tribes, and the lesions were located commonly in the rectum.
Conclusion We concluded that the rectum is the most common site of cancer within the Sudanese population than other parts of the colon with apparently high incidence within young ages.
... The current data showed that the mean age of the studied population was 51.1 years, with near half of the affected patients aged 50 years or less with no difference between males and females, our finding are going with researchers from Central Sudan [11] who concluded that 43.8% of Ca colon patients were below 50 years old, and male to female ratio of 1: 1.02 The current study reported that rectal bleeding and altered bowel habit were the commonest presentations among patients with colonic cancer in accordance with Mohamed et al. [12] who conducted a study in Sudan and concluded change in the bowel habit and rectal bleeding in 90.5%, and 84% respectively. Previous researchers [12, 13] observed that adenocarcinoma was the commonest histopathology among patients with Ca colon, in similarity with the present data in which 100% of patients were diagnosed with adenocarcinoma. ...
... The current study reported that rectal bleeding and altered bowel habit were the commonest presentations among patients with colonic cancer in accordance with Mohamed et al. [12] who conducted a study in Sudan and concluded change in the bowel habit and rectal bleeding in 90.5%, and 84% respectively. Previous researchers [12, 13] observed that adenocarcinoma was the commonest histopathology among patients with Ca colon, in similarity with the present data in which 100% of patients were diagnosed with adenocarcinoma. In the present study family history of colorectal cancer was evident in 16.7% (colonic cancer 10% and hereditary polyposis coli in 6.7%) similar to Taha et al. [11] who conducted a study in Khartoum Sudan and reported a family history in 15.06% of cases. ...
Background: There is a tendency of colorectal cancer towards a right shift, and increasing incidence among the young age groups. In this study, we aimed to assess the pattern of colorectal cancer among Sudanese patients attending an endoscopy unit in Omdurman Teaching Hospital. Subjects and Methods: This descriptive cross-sectional study conducted among thirty patients referred with the provisional diagnosis of colorectal cancer during the period from August 2015 to June 2016. Participants signed a written informed consent then interviewed to collect demographic data, symptoms related to carcinoma of the colon, the patients were then examined for evidence of anemia, intestinal obstruction, and ascites, colonoscopy with biopsy for histopathology was done. The ethical committee of the Omdurman Teaching Hospital approved the research, and the Statistical Package for Social Sciences (SPSS) was used for data analysis. Results; Out of thirty patients with the diagnosis of colorectal cancer, their ages ranged from 18-76 years with a mean of 51.1. The commonest presentations were rectal bleeding, change in the bowel habits, and constipation in 90%, 80%, and 60% respectively. Fourteen (46.7% were ≤ 50 years. The family history of colorectal cancer was evident in 16.7%, the recto-sigmoid area was the commonest site (83.3%), with 100% adenocarcinoma. Conclusion: Colorectal cancer tend to affect the younger age groups, the majority were recto-sigmoid (the proximal shift was not observed). The adenocarcinoma was the commonest histopathology.
The link between intestinal schistosomiasis and colorectal cancer has been suggested in previous studies. moreover, we had presented a case of sigmoid colonic adenocarcinoma associated with Schistosoma mansoni eggs in Sudan [1], a possible etiological role of chronic schistosomal infestation in colorectal cancer which might be an underlying cause of the endoscopic phenomenon that we called The Omer sign.
Background: Colorectal cancer is one of the most significant causes of cancer death. With records of high incidence and late detection of the disease in Sudan, and it was found to affect younger age groups.Methods: This study aimed to explore the incidence of colorectal lesions in the main endoscopic centers in Khartoum state- Sudan. It was a cross-sectional prospective study; data were collected from patients attending the main endoscopic centers in Sudan- Khartoum state during February 2013 to June 2014 including Khartoum teaching hospital, Neelain medical diagnostic center and Ibn sina hospital. Results: One hundred and six participants were diagnosed endoscopically with colorectal lesions, 44 (41.5%) showed inflammatory mucosa, 40 (37.7 %) showed tumor and 22 (20.7%) had polyps. In the whole group of patients the mean age was 45.7 years, 34.2% of tumor patients were less than 50 years old, 46.8% of the lesions were in the rectum, the highest frequency of tumor patients group were from western tribes, and the lesions were located commonly in the rectum. Conclusion: We concluded that the rectum is the most common site of cancer within the Sudanese population than other parts of the colon with apparently high incidence within young ages.
Background: Colorectal cancer (CRC) is the third most common cancer worldwide. The majority of cases occur in the developed world. This prospective study aimed to correlate different human leukocyte antigens (HLA types; HLA DRB1 and DRB3) with the aggressiveness of CRC in Sudanese patients. Methods: Thirty-three patients with histopathologically confirmed CRC were included in the study. Demographic, clinical and laboratory data were recorded. Molecular typing for HLA DRB1 (DR1, 7 and 17), DRB3 and DRB4 were carried out using PCR-based Sequence Specific Primers. Results: Forty percent of the patients were ≤ 50years; with a male to female ratio of 2.5:1. Rectal bleeding was the commonest presenting symptom. While moderately differentiated adenocarcinoma was the dominant histological type. Duke's stages B and C were reported in 54.6% and 42.4% of patients, respectively. No patients presented with Dukes stages A or D. HLA DRB3 was the most frequent allele detected followed by DRB4 and DR17. A higher frequency of the DRB3 allele was found in the peripheral blood when compared with the tumor and apparently normal tissues. HLA DRB3 and DR7 allele frequencies correlated with Duke's stages B and C but not with age, sex or degree of differentiation, while blood DR17 antigen correlated only with the degree of tumor differentiation. Conclusion: CRC was found to have a higher occurrence in younger patients. Tumors were aggressive with advance Duke's stage at presentation. This aggressive nature could possibly be related to either increased HLA DRB3 or DR7 or decreased HLA DR17 levels in the tumor tissue when compared with the blood. No differences between tumor and normal colon tissues were found, in concordance with the multifocally of colon cancer theory.
