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Activation barrier for the proposed mechanisms. Reaction energy and activation energy versus reaction progress
Source publication
In this study, magnetic nanoparticles (Fe3O4 NPs) were employed as good support for N-piperidine sulfamic acid to prepare a novel nanocatalyst (SA-PPCA–Fe3O4 NPs). This nanocatalyst was then characterized by different techniques such as FT-IR, XRD, TGA, SEM, TEM and VSM. The catalytic activity of the SA-PPCA–Fe3O4 NPs was studied by one-pot prepara...
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Citations
Pyridazine derivatives are a consequential class of heterocyclic compounds, which expose a wide range of distinguished biological activities. For example, pyridazine scaffolds are known as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosine kinase (TYK), janus kinase (JAK), tankyrase (TNKS), autotaxin (ATX), glyoxalase 1 (GLO-1), carbonic anhydrase (CA), aldose reductase (ALR), aldehdyde oxidase (AOX), excitatory amino acid transporter 2 (EAAT-2) activator, vascular endothelial growth factor receptor 2 (VEGFR-2), glutaminase 1 (GLS-1), α-glucosidase, α-amylase, cyclooxygenases 1 and 2 (COX-1 and COX-2), cyclin-dependant kinase (CDK), glycogen synthase kinase 3 (GSK-3), apoptosis signal-regulating kinase 1 (ASK-1), hedgehog (Hh) signaling pathway, sodium-glucose transport protein 2 (SGLT-2), hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD), factor XIa, stearoyl-CoA desaturase 1 (SCD-1), HIV-1 reverse transcriptase 1, monoamine oxidases A and B (MAO-A and MAO-B), tubulin polymerization topoisomerase Iiα (Topo Iiα), poly(ADP-ribose) polymerase (PARP), angiotensin-converting enzyme (ACE), phosphodiesterase (PDE), and many others. Furthermore, the mentioned heterocyclic frameworks exist in the structure of commercial drugs and agrochemical products. In addition, they have a decisive role in organic synthesis, especially as starting material in the pharmaceutically interesting compounds preparations. In this regard, the design and introduce simple, cost-effective, highly efficient, and selective synthetic strategies for the mentioned six-membered nitrogen-containing heterocyclic frameworks preparation are precious. This review has been covered almost all research papers that were described a series of arylglyoxal monohydrates-based one-pot multi-component protocols for the synthesis of various attention-grabbing potentially biologically active pyridazines. It is hoped that this review paper can be a little help to synthetic scientists, methodologists, and drug (or drug-like compounds) designers.
We have developed a SnO2/SiO2 catalyzed efficient and rapid protocol for the synthesis of pyrano[2,3-d]pyrimidinone derivatives by the three-component cyclocondensation of aromatic benzaldehydes, malononitrile, and barbituric acid in ethanol at room temperature. Nanocomposite SnO2/SiO2 catalytic materials were synthesized using the sol–gel method. The synthesized catalytic materials were well characterized by using a transmission electron microscope, X-ray diffraction spectroscopy, scanning electron microscopy, energy dispersive spectroscopy, Fourier transform infrared spectroscopy, temperature-programmed desorption (NH3-TPD), and Brunauer–Emmett–Teller theory. This protocol has several advantages such as high yield, simple workup procedure, non-toxic, clean, and easy recovery and reusability of the catalytic system.
Graphic abstract
An efficient catalytic system has been developed for the synthesis of pyrano[2,3-d]pyrimidinone derivatives from one-pot three-component cyclocondensation of aromatic benzaldehydes, malononitrile, and barbituric acid in ethanol at room temperature using 15 wt% SnO2/SiO2.
