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A couple was referred to our genetics department for cytogenetic analysis because of two previous abortions. The cytogenetic analysis of the male was found as 46, XY and the female revealed a balanced translocation; 46, XX,t (7;12) (p21;q14) and also she had 14 cenh+ as her mother. Atomic force microscopy (AFM) is a useful method for detecting deta...
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Context 1
... measurements revealed a 0.6 µm gap region (Figure 2). Besides we also analysed the satellite region of chromosome 14 (Figure 3) of the mother. ...
Context 2
... results of C-banding confirmed that these regions were belonging to heterochromatin region. Our 3- dimensional AFM analysis for the satellite region showed an augmentation on the short arm of this chromosome (Figure 3). These heterochromatin regions are polymorphic regions, and they are highly repetitive regions that are located on the centromeres of chromosomes 1, 9, and 16 and on the distal arm of Y chromosome (Burkholder and Duczek, 1980;Cook, 1995). ...
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Citations
... Since Atomic Force Microscopy (AFM) has been used to image human chromosomes, a more accurate documentation on the three dimensional structures of chromosomes has been developed. The height, width, volume, chromosomal aberrations, translocations, deletions, and other features are already reported for some karyotypes and specific chromosomes (Rasch et al., 1993;Zerrin et al., 2003;Jiao and Schäffer, 2004). Furthermore AFM images have been achieved either in native conditions, that is, in liquid, without previous treatment (Hoshi et al., 2006), or with different staining methods, giving parameters to detect even the chromosome's damage caused by analysis techniques (Kimura et al., 2004;Wu et al., 2006b). ...
The topographic structure of Giemsa-banded (G-banded) early metaphase human chromosomes adsorbed on glass was analyzed by atomic force microscope using amplitude modulation mode (AM-AFM). Longitudinal height measurements for early metaphasic human chromosomes showed a central ridge that was further characterized by transversal height measurements. The heterochromatic regions displayed a high level of transversal symmetry, while the euchromatic ones presented several peaks across the transversal height measurements. We suggest that this central ridge and symmetry patterns point out a transitional arrangement of the early metaphase chromosome and support evidence for interchromatidal interactions prior to disjunction.
