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A simplified rendition of the murburn SCE (Simple Chemical Engine) model of cell function, which depends on Effective Charge Separation (ECS) for cellular powering, thermogenesis, homeostasis, coherence, electrical activity, mobility, etc. (Please refer Manoj et al., 2022h for more details.) A simple fuel (like methane) can be burned or murburned in a simple chemical engine or cell (respectively) to produce water and carbon dioxide, liberating heat. Since the product of carbon dioxide is a gas, it can be easily voided. Since the other product is also the solvent, this leads to increase in water inside, which must spontaneously go out. In cells, this process leads to waste disposals and homeostasis. It must be noted that murburn concept does not necessitate oxygen's involvement; however, it serves life in a highly efficient way with dynamic roles of oxygen. When oxygen gets reduced in respiration or other metabolic processes, it transiently generates negatively charged species, which give electrical activity to the cells, and this process also networks cell and enables its powering (ATP synthesis).

A simplified rendition of the murburn SCE (Simple Chemical Engine) model of cell function, which depends on Effective Charge Separation (ECS) for cellular powering, thermogenesis, homeostasis, coherence, electrical activity, mobility, etc. (Please refer Manoj et al., 2022h for more details.) A simple fuel (like methane) can be burned or murburned in a simple chemical engine or cell (respectively) to produce water and carbon dioxide, liberating heat. Since the product of carbon dioxide is a gas, it can be easily voided. Since the other product is also the solvent, this leads to increase in water inside, which must spontaneously go out. In cells, this process leads to waste disposals and homeostasis. It must be noted that murburn concept does not necessitate oxygen's involvement; however, it serves life in a highly efficient way with dynamic roles of oxygen. When oxygen gets reduced in respiration or other metabolic processes, it transiently generates negatively charged species, which give electrical activity to the cells, and this process also networks cell and enables its powering (ATP synthesis).

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If evolution were to be a fact, a simplified and unifying approach to explain cellular physiology is warranted. Such a perspective should agree with the thermodynamic, kinetic, structural and the operational-probabilistic considerations; without invoking overt intelligence or determinism, and must enable a synthesis from chaos. In this regard, we f...

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... concept forms the founding pillars for cells functioning as the building block of life and provided the ambiance wherein central dogma could take shape in proto-cells. We can now understand that oxygen became the choice of oxidant because of the greater speed in reactions afforded by its intermediates and the facile modality in which the product of CO 2 could be expelled ( Figure 6). ...

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