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A representative karyotype image of this cases. The abnormal chromosomes were pointed out with red arrows. The ISCN description of this karyotype result as the following: //46,XY,der(2)t(2;3)(p21;q26.2),der(3)t(3;3)(q10;q10)add(3)(q26.2)t(2;3),del(20)(q11.2 q13.3).

A representative karyotype image of this cases. The abnormal chromosomes were pointed out with red arrows. The ISCN description of this karyotype result as the following: //46,XY,der(2)t(2;3)(p21;q26.2),der(3)t(3;3)(q10;q10)add(3)(q26.2)t(2;3),del(20)(q11.2 q13.3).

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Figure 1 Results of immunophenotype analysis during the initial workup...
Figure 2 A representative karyotype image of this cases. The abnormal...
Figure 3 FISH analyses in the initial bone marrow specimen in our...
Figure 4. Schematic illustration of hypotheses of leukemogenesis of...
Donor Cell-Derived Acute Myeloid Leukaemia with 3q26.2 Involvement/MECOM Rearrangement -A Case Report and Literature Review
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  • Dec 2020
Donor cell-derived leukaemia (DCL) is an uncommon complication of allogeneic hematopoietic stem cell transplantation (HSCT). DCL might represent up to 5% of the post-HSCT disease relapses, but case numbers reported in the literature might underestimate the frequency. The leukemogenesis of DCL is not well understood due to the limited numbers of cas...
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Context 1
... [13], indicating that these cells with chromosomal abnormalities were of donor cell origin ( Figure 2). Due to unavailability of the donor's genetic fingerprint information, XY FISH tests (probe from Abbott Molecular, Inc., Abbott Park, IL) were performed in both bone marrow and peripheral blood specimens and demonstrated that all cells were XY (donor) type, suggesting that our patient might have 100% myeloid engraft. ...