A photomicrograph of a transverse section of the rectal tissue revealed the followings: Panels (A, F, and K) showing control group closely packed simple tubular normal rectal crypts (RC) extending down to muscularis mucosa (MM) involved smooth muscle fibers, rectal crypts (RC) with narrow free space (balck arrow), and goblet cells (GCs) predominate in the glands with a normal size. Panels (B, G, and L) demonstrated DMH group with hyperplastic epithelial lesions., dilated, hyperplastic aberrant crypts, and cytoplasmic basophilia (BP) were seen. The apical part was overcrowded with cells of different heights. Also, these hyperplastic crypts showed distended goblet cells with partial mucin depletion. Panels (C, H, and M) revealed DMH+DADS group as normal crypts with somewhat crowded lamina propria. The upper segments of these crypts were characterized by goblet cells in normal size. Panels (D, I, N) showing DADS group with the same histological features as of control group. Panels (E, J, O) demonstrated preDADS+DMH group with the same features of DMH+DADS, with predominant normal goblet cells, and predominance of proliferating epithelial foci that might partially or totally occluded the lumen. Original magnifications as mentioned on each panel.  

Contexts in source publication

Context 1

... were aligned parallel to each other and extended down to muscularis mucosa. Lamina propria was appeared to fill the space between the crypts and contained mononuclear cells, and submucosal areolar connective tissue contains darkly stained lymphocytes ( Figure 1; panels A, F, and K). The mucosa has a smooth surface (no villi) and contains glands of Lieberkuhn. ...

Context 2

... mucosa of the rectum is similar to that of the colon but has fewer glands of Lieberkuhn. Basal parts of the crypts were lined by columnar cells with basal and oval vesicular nuclei ( Figure 1; panels A, F, and K). ...

Context 3

... RCC showed different criteria of epithelial hyperplasia. The most observed difference is the altered stain ability toward acidic dyes (cytoplasmic basophilia; BP) near the base of the lining cells of the RC (Figure 1; panels B, G, and L). Metaplasia squamation of epithelia in the intestinal glands and scarcity of connective tissue cells were observed ( Figure 1; Panel L) as compared to control. ...

Context 4

... most observed difference is the altered stain ability toward acidic dyes (cytoplasmic basophilia; BP) near the base of the lining cells of the RC (Figure 1; panels B, G, and L). Metaplasia squamation of epithelia in the intestinal glands and scarcity of connective tissue cells were observed ( Figure 1; Panel L) as compared to control. There were no signs of intraepithelial infiltration found in lymphocytes. ...

Context 5

... of DMH group co-treatment with DADS is reflected by the stain ability of the normal rectal crypts beside a scarcity of BP and the frequently observed connective tissue cells with somewhat crowded lymphocytes in lamina propria ( Figure 1; panels C, H, and M) as compared to DMH treated group. The upper segments of these crypts were characterized by goblet cells in normal size ( Figure 1; panel M). ...

Context 6

... of DMH group co-treatment with DADS is reflected by the stain ability of the normal rectal crypts beside a scarcity of BP and the frequently observed connective tissue cells with somewhat crowded lymphocytes in lamina propria ( Figure 1; panels C, H, and M) as compared to DMH treated group. The upper segments of these crypts were characterized by goblet cells in normal size ( Figure 1; panel M). ...

Context 7

... group with DAD showed the same organization observed in the control group (Figure 1; panels D, I, N). Normal epithelia with their complementary cell and connective tissue were observed. ...

Context 8

... protective group showed improvements in the rectal crypts and most of the described histological apparitions which were not DADS and control groups (Figure 1; panels D, I, N). Protection of DADS treatment is also reflected in the stain ability of the rectal crypts and the presence of connective tissue cells as compared to DMH treated group. ...