Figure 8 - uploaded by Nahla El-Eraky El-azab
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A photomicrograph of a longitudinal section of the gastrocnemius muscle of the myopathy group showing muscle disruption (MD), peripheral flat nuclei (arrow heads), large satellite cells (arrows), and widening of the endomysium (P).
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Background Myopathies are diseases of skeletal muscle, in which there is a primary functional or structural impairment. No standard therapeutic guidelines exist. The use of stem cells may provide dramatic advances in their treatment. Aim The aim of this study was to evaluate the potential therapeutic effect of bone marrow mesenchymal stem cells int...
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Context 1
... to the longitudinal axis of the fibers (Fig. 6). Group ΙΙ (the myopathy group) showed muscle disruption with loss of striation. Some fibers showed flat peripheral nuclei and others showed centrally located nuclei. Areas of muscle fiber loss and marked widening of endomysium were seen (Fig. 7). Large, multiple satellite cells were observed (Fig. 8). Group ΙΙI (the intramuscular stem cell group) showed nearly normal striated skeletal muscle fibers with slightly widened endomysium and loss of striation in some muscle fibers (Fig. 9). Many satellite cells were noticed (Fig. 10). Group ΙV (the intravenous stem cell group) showed a small area of muscle fiber destruction and indistinct ...
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Citations
... The waviness of myofibrils and sarcolemma may be explained by slippage of myofibrillar alignment due to muscle atrophy and disruption of the connection between the muscle fibrils and the sarcolemma as mentioned by (Kashef and Elswaidy, 2022). Some centrally located nuclei were noticed and explained by (Salem et al., 2016) as the newly regenerated myofibers had centrally located nuclei. We noticed also congested blood vessels with inflammatory cells that are stimulated by the degenerative changes of the muscles (Dias and Nylandsted, 2021). ...
... By the end of 30 days rats were sacrificed. Group III (D):Simvastatin was administered for 30 days by gastric gavage tube at a dose of 50 mg/kg body weight /day, and then after 15 days of simvastatin discontinuation rats were sacrificed.Group IV (M): Simvastatin was administered for 30 days at a dose of 50 mg/kg body weight/day by gastric gavage tube, with mesenchymal stem cells intravenous injection via rat tail vein once on day 31, each rat received 1x10 6 cells suspended in 0.5 mL of phosphatebuffered saline then rats were sacrificed after 15 days (18,19). Group V (F): Simvastatin was administered for 30 days by gastric gavage tube at a dose of 50 mg/kg body weight /day, then rats were submitted to a program of intermittent fasting for another 15 days. ...
... All of the previous findings were confirmed by the histopathological examinations. In the present study there was a structural change in gastrocnemius muscle that confirm myopathic changes of simvastatin, which is consistent with previous studies as (18,19,25). ...
... Also, resulted in Improvement of histopathological findings, decreased CK level by 79.201%, increased cross sectional area by 93.8976%, increased LC3 by 77.8719% and decreased P62 expression by 35.9429%, all as compared to the simvastatin group. In accordance, Farouk et al (18)and Salem et al (19)reported that mesenchymal stem cells administration has significant effects on improving simvastatin induced myopathy. ...
Statins are well-known lipid-lowering drugs. The pleiotropic effects of statins have brought about some beneficial effects on improving the therapeutic outcomes of cell therapy and tissue engineering approaches. In this review, the impact of statins on mesenchymal stem cell behaviors including differentiation, apoptosis, proliferation, migration, and angiogenesis, as well as molecular pathways which are responsible for such phenomena, are discussed. A better understanding of pathways and mechanisms of statin-mediated effects on mesenchymal stem cells will pave the way for the expansion of statin applications. Furthermore, since designing a suitable carrier for statins is required to maintain a sufficient dose of active statins at the desired site of the body, different systems for local delivery of statins are also reviewed.
