Figs 2 - uploaded by Neena Sood
Content may be subject to copyright.
A and B: (A) ×100 low power view showing papillae with cystic areas (B) ×400 high power view showing nuclear features of papillary carcinoma
Source publication
Papillary carcinoma arising in thyroglossal cyst is rare and is usually detected on postoperative histopathology after routine Sistrunk operation. Further management is a matter of debate and the choice lies between regular follow-up after Sistrunk operation or total thyroidectomy with or without radioiodine ablation and thyroxine suppression thera...
Similar publications
Objectives
Although it is well accepted that there is a close relationship between hypothyroidism and depression, previous studies provided inconsistent or even opposite results in whether subclinical hypothyroidism (SCH) increased the risk of depression. One possible reason is that the etiology of SCH in these studies was not clearly distinguished...
Introduction:
The presence of Thr92Ala polymorphism of deiodinase-2 (D2) may have several effects. It may influence its enzymatic function, is associated with increased expression of genes involved in oxidative stress in brain tissue, and may predict favorable response to combination levothyroxine (LT4) plus triiodothyronine (T3) therapy. We hypot...
Background:
Suboptimal thyroid hormone therapy including under-replacement and over-replacement is common amongst patients with hypothyroidism. This is a significant health concern as affected patients are at risk of adverse cardiovascular or metabolic consequences. Despite a growing body of evidence on the effects of various factors on thyroid ho...
Objective:
First-line treatment of thyrotoxicosis in young people is thionamide anti-thyroid drug (ATD) in a blocking dose with levothyroxine replacement (block and replace, BR) or in a smaller dose tailored to render the patient euthyroid (dose titration, DT). Our objective was to determine which regimen provides more stable biochemical control....
Citations
... Regularly, this duct obliterates, yet on the off chance that it stays patent, it might shape as a cyst that may be found in any place from foramen cecum to the thyroid isthmus. The majority of midline neck masses in children 5 are thyroglossal cysts .Individuals aged 1-82 years might have TGDC. The fourth decade of life is when it is most prevalent, with an expanded 2 pervasiveness in females than males (F:M, 3:2) . ...
... The mean period from the start of therapy to the recurrence was 42.1 months, representing a 4.3 percent recurrence rate. At the time of the most recent follow-up, all of the other participants were 8 disease-free, but one patient passed away with TGDC cancer .With a survival percentage of 95.6 percent in a decade, papillary carcinoma 5 emerging in TGDC has an outstanding prognosis . ...
Introduction: Papillary Carcinoma originating from thyroglossal duct cyst (TGDC) is very rare, occurring in less than one percent of cases. The diagnosis is often made in these situations following the removal of benign TGDC.We provide a case report that details a case of a thirty-years man who had Sistrunk's surgery for TGDC and was subsequently diagnosed to have Papillary Cancer.It is debatable how to handle these cases; the options include either a periodic monitoring following Sistrunk's Procedure or Complete thyroid gland excision +/- radio-active iodine (RAI) ablation and suppresive hormonal therapy. A th Case Presentation: irty-years man came to our OPD with anterior midline neck swelling which moved upward with deglutition and tongue protrusion.On radiology,distinct cystic lesion was seen. Sistrunk's Procedure was performed and tissue was sent for histo-pathological reporting. A papillary carcinoma foci was identied in the TGDC by histo-pathology. As a follow up and completion treatment, our patient was subjected to complete thyroidectomy. The most Discussion: frequent anomalies are TGDC which are encountered in thyroid development. Within TGDC remains, malignancy is present in one to two percent of cases with most being Papillary Carcinoma. TGDC are most common in females with ratio being 3:2.
Objective
Although thyroglossal duct cysts (TGDCs) are relatively common, malignancies within these lesions are infrequent. As a result, there are no large-scale series describing clinical characteristics. Our objectives were to perform a systematic review of the literature evaluating patient demographics, pathology, management, and prognosis of these patients.
Data Sources
PubMed, Embase, Cochrane reviews, and Google Scholar were searched for relevant articles. Articles meeting inclusion criteria were reviewed for data detailing epidemiology, treatment, and outcomes.
Review Methods
Inclusion criteria included English-language articles with original reports on human subjects. Two investigators independently reviewed all articles for the data collected, including epidemiology, treatment, and outcomes.
Results
Ninety-eight articles comprising 164 patients were included in the final analysis. The mean age at presentation was 39.5 years (9-83 years); 68.3% of patients were female. In total, 73.3% of cases were found on final pathologic analysis. The most common pathology was papillary cancer (92.1%). Of the patients, 98.9% underwent a Sistrunk procedure and 61.0% underwent total thyroidectomy. There was a 4.3% recurrence rate with a mean time to recurrence of 42.1 months from initial treatment. One patient died of TGDC carcinoma, while all other patients were disease free at the time of last follow-up (mean follow-up was 46.1 months).
Conclusion
TGDC carcinoma is typically diagnosed on final pathology. While management encompasses a Sistrunk procedure, further consideration should be given to thyroidectomy among patients ≥45 years of age and individuals with aggressive disease. TGDC carcinoma harbors an exceedingly low rate of mortality.
