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(A) The glomeruli appear normal in terms of cellularity and size. There is no crescent formation, tubular atrophy, interstitial fibrosis, or interstitial inflammation (Light microscopic examination, PAS, ×400). (B-H) The tubular basement membrane shows focal granular staining (IgA, IgG, IgM, C3, C1q, kappa, and lambda immunofluorescence) (Immunofluorescence staining, ×400).
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Histopathologic evidence of "full-house" immune complex deposits is a pathognomonic feature of lupus nephritis. This report presents the case of a 12-year-old boy with persistent microscopic hematuria and proteinuria. He was diagnosed with "full-house" nephropathy based on a renal biopsy. However, there was no other clinical or biological evidence...
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Context 1
... 10-19/HPF), and 70% dysmorphic red blood cells (RBCs); urine cultures were negative. The daily urinary protein excretion was 3.1 mg/ m 2 /hour and the glomerular filtration rate (GFR) was 129.2 mL/min/1.73m 2 . Abdominal ultrasound was normal. A renal biopsy showed normal-looking glomeruli in terms of cellularity and size on light microscopy (Fig. 1A). Immunofluorescent microscopy revealed the "full-house" pattern of IgG, IgA, IgM, C3, C1q, kappa and lamda positive deposition in the glomerular area ( Fig. 1B-H). Electron microscopy showed variable sized subendothelial and subepithelial deposition and some mesangial deposition in the glomeruli ( Fig. 2 A and B). No cytoplasmic ...
Context 2
... filtration rate (GFR) was 129.2 mL/min/1.73m 2 . Abdominal ultrasound was normal. A renal biopsy showed normal-looking glomeruli in terms of cellularity and size on light microscopy (Fig. 1A). Immunofluorescent microscopy revealed the "full-house" pattern of IgG, IgA, IgM, C3, C1q, kappa and lamda positive deposition in the glomerular area ( Fig. 1B-H). Electron microscopy showed variable sized subendothelial and subepithelial deposition and some mesangial deposition in the glomeruli ( Fig. 2 A and B). No cytoplasmic tubuloreticular inclusions were identified in the current ...
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A number of kidney diseases of childhood may present as isolated proteinuria or/and hematuria, without any overt signs or symptoms. Urinalysis is a simple and inexpensive test used to evaluate various renal disorders. A school urine screening (SUS) program for kidney disease was conducted in Korea in 1998. Several research reports, including case r...
Citations
Full-house staining of glomeruli in renal pathology is highly suggestive of lupus nephritis. Other nonlupus entities can also present with a similar pattern on immune fluorescence. Different authors have used different names for this new entity with full house staining on immunofluorescence (IF) with negative serology for lupus. Some authors used the term full-house nephropathy for this new entity. The aim of our study is to define the clinicopathological spectrum and treatment outcomes of nonlupus "full-house" patterns. We retrospectively reviewed all renal biopsies performed between 2013 and 2017 in the nephrology department in a tertiary teaching hospital in south India. A total of 12 patients were found with full-house staining on IF, not fulfilling the American College of Rheumatology criteria for SLE. Out of 12 patients, eight patients (66%) presented with features suggestive of both nephrotic and nephritic syndrome, one patient (8%) with subnephrotic proteinuria, one patient (8%) with rapidly progressive glomerulonephritis, one patient (8%) with pure nephrotic syndrome, and one patient (8%) with pure nephritic syndrome. The most common histopathology pattern observed was diffuse proliferative glomerulonephritis (58%), followed by membranous nephropathy (16%), membranoproliferative glomerulonephritis (16%), and mesangioproliferative glomerulonephritis (8%). Irrespective of treatment regimen given, six patients (50%) achieved complete remission, three patients (25%) achieved partial remission, and three patients (25%) did not attain remission at the end of six months. Only one patient became ANA positive during follow-up. Thus, we can conclude that varied glomerular pathologies can occur with full house pattern on IF which respond well to immunosuppression.
