Figure - available from: Head and Neck Pathology
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A Squamous papilloma. A sessile lesion with short papillary projections on the right maxillary buccal gingiva. B Papillary proliferation of keratinized stratified squamous epithelium, magnification X40 (H&E*). C High power view demonstrating the fibrovascular connective tissue cores,, magnification X200 (H&E*). D Verruca Vulgaris. Exophytic, white, papillary lesion of the mid-hard palate. E, Numerous papillary epithelium proliferation covered by severely thickened layers of spire-like orthokeratin. Elongated rete ridges at the edge of the lesion converge toward the center, magnification X40 (H&E*). F High-power view demonstrating clear koilocytes in the upper epithelial layers, magnification X400 (H&E*). G Condyloma Acuminatum. A pedunculated mass on the left lower lip, exhibiting blunted surface projections. H Papillary proliferation of stratified squamous epithelium forming a blunted projection, overlying supporting fibrous connective tissue, magnification X40 (H&E*). I Mitosoid bodies (yellow circle) demonstrate the viral cytopathic effects in the spinous layer, magnification X400 (H&E*). *Hematoxylin-eosin staining
Source publication
Human papillomavirus (HPV)-related benign papillary epithelial neoplasms are common lesions affecting any region of the oral cavity. This study evaluated the trends in frequency, location, and demographics of these lesions over 20 years in a large biopsy service. Following IRB approval, the archives of UF Oral Pathology Biopsy Service between 1995...
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Citations
... Although oral HPV infections are usually subclinical and spontaneously regress within 1-2 years of infection, chronic disease is observed in a minority of patients. [2][3][4][5] Herein, we present a patient with a neglected large wart on the tongue that has been around for 15 years and removed with excisional surgery. ...
... However, there can also be non-sexual transmission routes such as autoinoculation, contaminated objects, and maternofetal transmission at birth. 2 The carriage rate of HPV in oral mucosa in healthy individuals is approximately 7.7%, according to a recent meta-analysis. 6 The incidence of lesion detection due to the HPV virus in the oral cavity is around 3%. 7 Although the lesions can be seen anywhere in the oral cavity, the lips, palate, and tongue are the most frequently affected areas. ...
... Epithelium showed hyperkeratosis, hypergranulosis and intraepithelial hemorrhage (on right side)The clinical appearances of the lesions vary from benign, hyperplastic, papillomatous, and verrucous lesions to carcinomatous changes, depending on the infected HPV type and body region. The lesions can be seen in pink/white colours depending on the keratinization characteristics of the tissue they are located.2,4 Verruca vulgaris lesions in the oral cavity are usually seen as solitary, papillomatous, whitish, sessile and exophytic masses, and multiple or verrucous or pedunculated lesions may also be seen. ...
Verruca vulgaris is a benign infection caused by the human papillomavirus (HPV). The lesions appear primarily on the cutaneous surfaces; however, mucosal involvement is less frequent. The typical presentation is asymptomatic papules varying in size and number. The differential diagnosis includes a diverse list of benign and malignant conditions. Herein, we present a 65-year-old male patient with an asymptomatic cauliflower-like mass on the tongue incidentally observed during internal medicine physical examination. The excisional biopsy revealed verruca vulgaris, and no new lesions were detected in the follow-up.
