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A Macrographs illustrating the neuronal enlargement of somata seen in the heart failure group (4Ai and ii)(n = 7) when compared to the control (n = 11) group (4Aiii and iv). Micrograph highlighting the lack of neuronal enlargement in the right atrial region in the heart failure group (4Av). B MI induced morphological changes in neuronal somata within the rabbit ICNS. The average overall cell area was quantified and compared between hearts from CTL (green)(n = 11 (10777), SHM (blue)(n = 4 (3419) and HF (red)(n = 7 (3902)) (4Bi). The average cell area was increased significantly in all regions examined apart from the region of the right atrial ganglionated plexus (4Bii). Representations of the distribution of cell size are shown in Biii, with Biv indicating ganglionic sites and highlighting the right atrial region (red circle). n = number of animals (number of cells). Data are represented as mean ± SEM. Statistical analysis performed with repeated measures two-way ANOVA, with Bonferroni post-hoc test. ns = no significance, ***p < 0.001, ****p < 0.0001. Abbreviations: CA, conus arteriosus; RA, right atrial; vPV, ventral pulmonary veins; RCV -right cranial vena cava; LCV -left cranial vena cava; LPV/MPV/RPV -left, middle, right pulmonary vein; DRA/VRA -dorsal/ventral right atrium; VLA -ventral left atrium; RAu -right auricle. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
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Aims
Heart failure is a clinical syndrome typified by abnormal autonomic tone, impaired ventricular function, and increased arrhythmic vulnerability. This study aims to examine electrophysiological, structural and neuronal remodeling following myocardial infarction in a rabbit heart failure model to establish its neuro-cardiac profile.
Methods and...
Contexts in source publication
Context 1
... the average cell area (μm 2 ) in control animals was 601 ± 45, with no significant regional variation. Conversely, in all HF hearts, there was significant neuronal enlargement ( Fig. 4A and B, P < 0.0001). The degree of neuronal enlargement in the HF group was spatially diverse. The most significant difference in neuronal size was observed within the region of the heart hilum (HF: 1185 ± 31 μm 2 vs CTL: 632 ± 60 μm 2 vs SHM: 652 ± 50 μm 2 ). In comparison, neuronal somata from the right atrial region of HF hearts ...
Context 2
... diverse. The most significant difference in neuronal size was observed within the region of the heart hilum (HF: 1185 ± 31 μm 2 vs CTL: 632 ± 60 μm 2 vs SHM: 652 ± 50 μm 2 ). In comparison, neuronal somata from the right atrial region of HF hearts showed no significant enlargement (HF: 752 ± 132 μm 2 vs CTL: 567 ± 68 μm 2 vs SHM: 496 ± 32 μm 2 (Fig. ...
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