Figure 3 - uploaded by Ali Ayyad
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(A) Light microscopic view showing several destructive necrotizing granulomas infiltrating the brain tissue with numerous multi-nucleated giant cells (H&E ×100). (B) High microscopic image showing granuloma engulfing fungal hyphae-yellow arrow (H&E ×400). (C) Gomori's methenamine silver stain highlighting acutely branched (red arrow) and septate (yellow arrow) fungal hyphae (GMS ×600).
Source publication
Introduction: Intracranial fungal infection is uncommon condition with high morbidity and mortality. Recently, the incidence has increased owing to the increase of the number of immunocompromised patients (e.g., acquired immunodeficiency syndrome, uncontrolled diabetes mellitus, immunosuppressive drugs, and organ transplant). Furthermore, intracran...
Contexts in source publication
Context 1
... resonance image of head was done postop day 1 showed near total resection of the previously seen left frontal intracranial mass with no definite extra-axial definite component (Figure 2A-C). Histopathology showed brain tissue as well as sclerotic/fibrotic tissue that were heavily infiltrated by ill-defined destructive granulomas having numerous multi-nucleated giant cells ( Figure 3A) surrounded by lymphocytes as well as macrophages, some of these granulomas showed shadows of branching fungal hyphae ( Figure 3B). Grocott's methenamine silver stain (GMS) and Periodic acid-Schiff (PAS) stains for fungi highlighted the fungal hyphae which turned to be acutely branched and septate fungal hyphae ( Figure 3C) which were negative by mucin stain. ...
Context 2
... resonance image of head was done postop day 1 showed near total resection of the previously seen left frontal intracranial mass with no definite extra-axial definite component (Figure 2A-C). Histopathology showed brain tissue as well as sclerotic/fibrotic tissue that were heavily infiltrated by ill-defined destructive granulomas having numerous multi-nucleated giant cells ( Figure 3A) surrounded by lymphocytes as well as macrophages, some of these granulomas showed shadows of branching fungal hyphae ( Figure 3B). Grocott's methenamine silver stain (GMS) and Periodic acid-Schiff (PAS) stains for fungi highlighted the fungal hyphae which turned to be acutely branched and septate fungal hyphae ( Figure 3C) which were negative by mucin stain. ...
Context 3
... showed brain tissue as well as sclerotic/fibrotic tissue that were heavily infiltrated by ill-defined destructive granulomas having numerous multi-nucleated giant cells ( Figure 3A) surrounded by lymphocytes as well as macrophages, some of these granulomas showed shadows of branching fungal hyphae ( Figure 3B). Grocott's methenamine silver stain (GMS) and Periodic acid-Schiff (PAS) stains for fungi highlighted the fungal hyphae which turned to be acutely branched and septate fungal hyphae ( Figure 3C) which were negative by mucin stain. Glial fibrillary acidic protein (GFAP) highlighted the end infiltrated brain parenchyma between the granulomas. ...
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