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A. Immunofluorescence images taken at 400x magnification. YBX2 staining localizes to spermatocytes and round spermatids among normal samples. Significant loss of both YBX2 and PRM2 are visualized in LMA. Negative controls do not demonstrate positive staining intraluminally. 

A. Immunofluorescence images taken at 400x magnification. YBX2 staining localizes to spermatocytes and round spermatids among normal samples. Significant loss of both YBX2 and PRM2 are visualized in LMA. Negative controls do not demonstrate positive staining intraluminally. 

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Figure 1. RNASeq normalized transcripts among normal controls and...
Figure 2. Identifiable cell types in normal and late maturation arrest...
Figure 3 A. Immunofluorescence analysis of expression of YBX2 protein...
Figure 3B. Flow cytometry (left) and immunofluorescence (right) of a...
+1 Figure 5A. Immunofluorescence images taken at 400x magnification. YBX2...
YBX2 Dysregulation is a Potential Cause for Late Maturation Arrest in Men with Non-Obstructive Azoospermia
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  • Jul 2018
Introduction: YBX2 protein binds to Y-box promotors and to mRNAs in the cytoplasm of pachytene spermatocytes and round spermatids in rodents. Knock-out of YBX2 leads to maturation arrest in animal models. YBX2 binds PRM1 and 2 mRNA, which is transcribed early and sequestrated for translation during late spermatogenesis. Objective: This study aimed...
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