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(A) Disarticulation of the hip was performed two weeks later from the last operation. (B) A posteroanterior radiograph of the chest revealed diffuse haziness over the entire left lung field, with pleural effusion.
Source publication
Malignant vascular tumors (angiosarcoma) of bone are rare and represent a less than 1% of malignant bone tumors. The authors report a case of a patient with angiosarcoma misdiagnosed as infection, which developed adjacent to a stainless steel intra-medullary nail used for fixation of a femur fracture.
Contexts in source publication
Context 1
... harvested some tissues for biopsy. Antibiotic beads were inserted in the distal femur, and the femur was externally fixed to prevent any further progression of the pseudoarthrosis ( (Fig. 3). The patient was transferred to an advanced medical institution, Consequently, disarticulation of the hip was performed 2 weeks later from the last operation (Fig. 4A), and three courses of chemotherapy including isosfamide 2500 mg/m 2 , mesna 2500 mg/m 2 , and adriamycin 60 mg/m 2 were started. The pa- tient was followed-up for 3 years. However, 41 months after the last surgery, he admitted to an emergency room complaining of fever and dyspnea and he was diagnosed with pneumonia. Even though he was ...
Context 2
... , and adriamycin 60 mg/m 2 were started. The pa- tient was followed-up for 3 years. However, 41 months after the last surgery, he admitted to an emergency room complaining of fever and dyspnea and he was diagnosed with pneumonia. Even though he was treated with conservative treatment for the disease, he finally expired 10 days after the admission (Fig. ...
Citations
Angiosarcomas are rare and highly malignant soft tissue sarcomas originating from endothelial cells lining the lymphatic or vascular system. While they predominantly emerge from (sub)cutaneous regions, occurrences have been reported throughout the body. The etiology of angiosarcoma remains elusive in most clinical cases. Nevertheless, several prognosis risk factors play a pivotal role, including chronic lymphedema, therapeutic irradiation, environmental carcinogens, familial syndromes, and the presence of foreign materials like metallic objects and biomedical implants. Despite evidence implicating retained foreign material in angiosarcoma development, understanding its prognosis and pathogenesis remains limited. The pathogenesis of angiosarcoma appears to involve a complex interplay of chronic inflammation, tissue remodeling, and genetic factors that create a conducive microenvironment for malignant transformation. Management of these sarcomas remains challenging due to their infiltrative nature owing to the high chance of metastasis and local recurrence. The primary treatment modalities currently include surgery, radiotherapy, and chemotherapy, but recent advances in targeted immunotherapy and gene therapy hold promise for more effective approaches. This comprehensive review delves into the potential etiological and pathogenic roles of foreign materials, such as metallic objects, biomedical implants, and biomaterials, in the development of angiosarcoma. Further research into the underlying molecular mechanisms could provide valuable insights for tailored management and developing novel targeted therapeutic strategies.
