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A) Conventional smear showing clusters of spindle-shaped cells (Pap stain × 200), B) DOG-1 is negative in the neoplastic cells (× 200), C) SMA is strongly positive in the neoplastic cells, D) CELLBLOCK, E) conventional smear showing clusters of spindle-shaped cells with round nuclei (Pap stain × 400).
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Esophageal lyomyoma are rare benign tumors of the esophagus and they remain usually undiagnosed until local compression symptoms occur in the esophagus. Gastroscopy or esophageal ultrasonography (EUS) are usually the methods of choice for diagnosis. Moreover; surgery is the solution for this entity. In our case we present diagnosis of esophageal ly...
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Background:
Several studies have reported the efficacy of esophageal ultrasound-guided fine needle aspiration (EUS-FNA) for the detection of metastases in the left adrenal gland (LAG) in patients with lung cancer. Currently we have only limited evidence based on small studies on the usefulness of EUS-B [endobronchial ultrasound (EBUS) scope into t...
Citations
... Endobronchial ultrasound is an effective minimal invasive diagnostic tool for initial evaluation. [9][10][11][12] ...
Bronchogenic cysts are rare congenital malformations which derive from primitive ventral foregut. They are usually observed in intrathoracically. A fifty year old male was admitted for the investigation of a three month chest pain. Computed tomography scan of the thorax revealed a lesion around the esophagus and left stem bronchus. Endobronchial ultrasound with convex probe and a 19G needle biopsy revealed a bronchogenic cystic which was removed with video assisted thoracic surgery. Initial radiologic assessment although was thought to be lung cancer because of the smoking habit it turned out to be benignancy. EBUS-TBNAB with 10G needle is safe and absolutely necessary for these lesions, as they take large samples.
... The CP-EBUS system can be used for the diagnosis of paraesophageal lesions and has been used on several occasions [10,11]. Based on the expertise of every pulmonary center, this approach is feasible and safe [12]. ...
Lung cancer is still diagnosed at a late stage due to lack of early disease symptoms. Despite the development of new diagnostic endoscopic tools, such as radial/convex endobronchial ultrasounds (EBUS) and electromagnetic navigation, most patients are still diagnosed at advanced stage disease. Most of the patients refer to their doctor only if they cough blood or their cough changes character. There are challenging cases in the diagnosis and staging of a patient, such as the one that we will present. We present a case of lung cancer that was diagnosed through a biopsy from the main lesion, with access from the esophagus, through transbronchial needle aspiration with EBUS, under general anesthesia and intubation. Staging with transbronchial needle aspiration with EBUS was also performed at the same session.
... Convex-Probe endobronchial ultrasound is used for the diagnosis of central masses/lymphadenopathy and lung cancer staging. [8][9][10] It has been observed that the samples obtained from the needles are efficient for investigation of several genes. [11][12][13] Epidermal growth factor (EGFR), anaplastic lymphoma kinase (ALK), ROS proto-oncogene 1 (ROS1), proto-oncogene B-Raf (BRAF) and programmed death-ligand 1 (PD-L1) can be investigated in the sample of a 21G, 22G and 19G needle that convexprobe EBUS is using [12]. ...
Introduction: Lung cancer is diagnosed at advanced stage due to lack of early disease symptoms. Currently we have several different biopsy techniques such as; radial endobronchial ultrasound, convex probe endobronchial ultrasound, electromagnetic navigation, ct guided biospy and transthoracic ultrasound biopsy. Novel therapies such as; immunotherapy is being used for non-small cell lung cancer in the everyday clinical practice as first and second line treatment. Programmed ligand-1 is essential in order to administer immunotherapy as first line treatment.
Patients and Methods: Two thousands and two patients were included in our study where programmed ligand 1 was evaluated with DAKO technique and BIOCARE®. Cell blocks were obtain with convex probe ebus-tbna 22G needle.
Results: The Deming regression between DAKO and BIOCARE clone revealed an amazingly strong linear relationship as the coefficient of determination indicated (R²=0.999) and the variance ratio close to 1 (0.978), proving that both techniques can equally well be substituted for each other. The regression coefficient equals to 1 and the intercept hardly differs from 0 (0.936). In practice, this relationship permits adopting the economically affordable BIOCARE clone for further medical considerations.
Conclusion: No statistical difference was observed between DAKO and BIOCARE®, therefore we propose that both techniques can be used in order to investigate the expression of programmed ligand 1 with safety. PD-L1 expression was higher in the central mass instead of the lymphnodes.
Introduction
Thyroid cancer is usually diagnosed both with imaging techniques and transdermal biopsy. Laboratory tests are also included in the initial work-up.
Patients and Methods
One hundred and thirty patients were included in our study with pathological imaging findings in the thyroid region. Biopsies were performed with 22G with transdermal convex probe, EBUS 22G Mediglobe® needle and 19G Olympus® needle. We investigated the efficiency and safety of both techniques and identified the best candidates for each method.
Discussion
19G needle identified cancer types such as; Lymphoma, Medullary thyroid cancer and Hurthle cell cancer, which we know from previous pathology studies that a larger sample is necessary for diagnosis. No safety issues were observed for both techniques and the EBUS technique produced more cell block material when 22G needle was compared to transdermal biopsy in peritracheal lesions.
Conclusion
The method of biopsy should be made based on the size and accessibility of the lesion.
