Fig 1- - uploaded by Marco Benazzo
Content may be subject to copyright.
A, B) Laryngeal endoscopy shows a bulging lesion of the left aryepiglottic fold and a superficial vegetation extending from the left aryepiglottic fold to the anterior and medial wall of the apex of the left pyriform sinus (arrow). (C, D) Computed tomography scan reveals a contrast-enhancing 20 × 11 mm lesion of the right false vocal cord extending laterally to the paralaryngeal fat (arrow) and a second area of contrast enhancement in the contralateral aryepiglottic fold and anterior wall of the apex of the pyriform sinus (arrows).
Source publication
Purpose:
A collision tumor consists of 2 different histologically distinct and topographically independent tumors merging in the same mass. In the head and neck region they are rare, with only 4 cases reported in the larynx.
Case report:
A 60-year-old heavy smoker complained of a left submandibular lesion in October 2014. The lesion was excised...
Context in source publication
Context 1
... attention with the diagnosis of left submandibular metastasis of a poorly differ- entiated adenocarcinoma. Computed tomography (CT) scan showed a 20 × 11 mm lesion of the right false vocal cord, bi- lateral lymphadenopathies, and contrast enhancement in the left pyriform sinus, where NBI fiber endoscopy documented a pathologic vascular pattern (Fig. 1). A biopsy from this area was positive for moderately differentiated SCC. Gross exami- nation of the circular pharyngolaryngectomy surgical sample showed a 3 × 2.5 cm lardaceous submucosal mass in the right glottis and a 2 × 2.5 cm keratotic mucosal thickening of the left pyriform ...
Similar publications
Introduction
Sarcopenic dysphasia is a relatively new disease concept describing impairments in swallowing resulting from a generalized loss of skeletal muscle mass.
Presentation of case
In this case report, we describe the clinical history and presentation of a 76-year-old man who developed mild sarcopenic dysphasia following a period of physical...
Citations
... Collision tumors in the head and neck area are rare, and they have been described mostly in the thyroid. Collision tumors affecting the larynx are extremely rare; only a few cases have been described [4][5][6][7][8][9][10][11], and none of this work described more than two histological reports. ...
... The definition of collision carcinoma is controversial, with different researchers having different interpretations. Some believe that collision carcinoma can occur in adjacent organs, and that the tumors can eventually invade each other [6][7][8] . Kufeld et al [6] reported a case of collision carcinoma of hypopharyngeal adenoid cystic carcinoma and laryngeal SCC. ...
... Kufeld et al [6] reported a case of collision carcinoma of hypopharyngeal adenoid cystic carcinoma and laryngeal SCC. Marangoni et al [7] reported carcinomas colliding in the aryepiglottic fold of hypopharyngeal SCC and laryngeal NEC. Jacobson et al [8] reported a case of papillary thyroid carcinoma and laryngeal SCC. ...
... Jacobson et al [8] reported a case of papillary thyroid carcinoma and laryngeal SCC. They suggested that this was a case of collision carcinoma [6][7][8] . Some researchers have posited that a benign tumor and a malignant tumor, or two benign tumors, occurring in one organ at the same time can also be considered as collision carcinoma [9] . ...
BACKGROUND Collision carcinoma is rare in clinical practice, especially in the head and neck region. In this paper, we report a case of squamous cell carcinoma (SCC) and neuroendocrine carcinoma (NEC) colliding in the larynx and review 12 cases of collision carcinoma in the head and neck to further understand collision carcinoma, including its definition, diagnosis, and treatment. CASE SUMMARY A 61-year-old man presented with a 1-year history of hoarseness. Contrastenhanced magnetic resonance imaging of the larynx revealed that the right vocal cord had a nodule-like thickening with obvious enhancement. Laryngoscopy revealed a neoplasm on the right vocal cord, and a malignant tumor was initially considered. A frozen section of right vocal cord was performed under general anesthesia. The pathological result showed a malignant tumor in the right vocal cord. The tumor was excised with a CO2 laser (Vc type). Routine postoperative pathology showed moderately differentiated SCC with small cell NEC in the right vocal cord. No metastatic lymph nodes or distant metastases were found on postoperative positron emission tomography/computed tomography. Because of the coexistence of SCC and NEC, the patient received adjuvant chemotherapy and radiotherapy. The patient was followed for 8 mo, and no recurrence or distant metastasis was found. CONCLUSION The treatment of collision carcinoma in the head and neck region is uncertain due to the small number of cases.
Background:
The definition of "collision tumor" is the coexistence of two histologically and morphologically distinct tumors within the same anatomical area without histological admixture. Collision tumors featuring primary squamous cell and adenoid cystic carcinomas of the hypopharynx, combined with synchronous esophageal carcinoma, are very rare.
Methods:
We describe a patient with a collision tumor of the hypopharynx and synchronous esophageal carcinoma who underwent partial laryngectomy, with preservation of laryngeal function, and radical esophageal resection featuring esophageal reconstruction using a gastric tube. Surgery was successful.
Results:
Postoperative radiotherapy was recommended after surgery; the patient exhibited no recurrence or distant metastasis to the 17-month follow-up.
Conclusion:
To the best of our knowledge, this is the first report of collision of primary squamous cell carcinoma and adenoid cystic carcinoma in the hypopharynx and synchronous esophageal carcinoma. We performed appropriate surgery and prescribed postoperative radiotherapy. This preserved laryngeal function.
The poorly differentiated neuroendocrine carcinomas (NECs) of the larynx are rare tumors that comprise of a small cell-type (SCNEC) and a large cell-type (LCNEC). In order to consolidate the current knowledge about their characteristics and management a systematic review of the available literature was performed. The PubMed/Medline and Scopus databases search resulted in 141 articles published between 1972 and 2019, describing 273 patients: 230 cases were of SCNEC histology (84.2%) and 43 cases were LCNECs (15.8%). Comparing both histological entities, patients with LCNECs were older (63.2 vs. 58.7 years, p = 0.036) than SCNEC patients and had more often primary tumor in a supraglottic larynx (79.5 vs. 56.1%, p = 0.039), advanced-stage neck disease (N2-3, 56.8 vs. 40%, p = 0.061), surgery-based treatment (83.7 vs. 51.9%, p < 0.001) and had no radiotherapy (44.2 vs. 29%, p = 0.071). At presentation, systemic metastases were diagnosed in 12.1% of the patients, whereas disease relapse was experienced by two-thirds (65.3%) of those initially staged M0; systemic relapse, alone or in combination with local/regional recurrence, was the most frequent type of failure (in 71.9%). On multivariate analysis, more advanced disease stage and SCNEC histology adversely influenced disease-specific survival. Wide variations in the pattern of care, including radiotherapy doses and chemotherapy regimens, were found among long-term survivors without known disease at ≥ 24 months of follow-up (N = 36). We conclude that the most effective treatment for poorly differentiated NECs has yet to be determined.
