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(A) A 15-mm pink nodule of hard consistency on the dorsum of the tongue. (B and C) Vascular lobules, comprising endothelial cell aggregates, in the dermis (haematoxylin and eosin). C Inset. More that 90% of cells were positive for CD34. doi: 10.2340/00015555-1019
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Context 1
... 34-year-old woman, in her fourth month of pregnancy, presented with an isolated exophytic lesion of the tongue, which had developed 2 months previously and which caused discomfort when swallowing. On examination, we found a pink nodule (diameter 15 mm) of hard consistency on the dorsum of the tongue (Fig. 1A). A cutaneous examination revealed nothing abnormal. Analysis of a biopsy ...
Context 2
... of 1 Dermatology and 2 Pathology, San Cecilio University Hospital, Av Dr. Oloriz 16, ES-18012 Granada, Spain. E-mail: salvadorarias@hotmail.es revealed multiple separate vascular lobules within the dermis, each composed of aggregates of endothelial cells (Fig. 1B). Cells were positive for CD34 (Fig. 1C), and ne- gative for Factor VIII, HHV-8 and androgen, estrogen and progesterone ...
Context 3
... of 1 Dermatology and 2 Pathology, San Cecilio University Hospital, Av Dr. Oloriz 16, ES-18012 Granada, Spain. E-mail: salvadorarias@hotmail.es revealed multiple separate vascular lobules within the dermis, each composed of aggregates of endothelial cells (Fig. 1B). Cells were positive for CD34 (Fig. 1C), and ne- gative for Factor VIII, HHV-8 and androgen, estrogen and progesterone ...
Citations
... In addition, female hormones increase the production of angiogenic factors, such as the basic fibroblast growth factor and the vascular endothelial growth factor which leads to the appearance of pyogenic granuloma [5] . literature review of pyogenic granuloma of the tongue including the case reports illustrated in (Table1) [6,7,8,9,10,11,12,13] . Clinically, it is a small, deep red to purple lesion which can be sessile or pedunculated. ...
... In general, treatment during pregnancy is
necessary if the lesion causes functional or aesthetic harm. On the other hand, its surgical
excision is indicated after pregnancy2. The
control of the bacterial biofilm is of great importance to prevent recurrence after
treatment5,7. ...
Granuloma gravidarum (GG) is an inflammatory lesion, which develops in the oral mucosa of
pregnant women in response to chronic low-grade irritants, under the influence of hormonal
factors.Objective:To characterize GG clinically by means of a retrospective study of the cases of the
Oral Medicine Division, São Lucas Hospital, Brazil.Material and Methods:Cases of GG diagnosed between 1980 and 2012 were analyzed. Data were obtained
referring to the age of the patients, lesion location, clinical features, as well as the
presence of local irritants. The gestation period in which the lesion developed was also
investigated. Results:Forty-one cases of GG were found. The lesions developed predominantly in the third
trimester of pregnancy (51.22%) and the mean age of the patients was 28 years. Most GG
was found in the gingiva (73.17%), was reddish color and had a mean diameter of 1.5 cm.
Local irritants were involved in 75.6% of the cases.Conclusions:The hormonal conditions of pregnancy can have an impact on the oral cavity,
predisposing the patient to inflammatory lesions such as GG.
Aim:
Aim of the study was to assess whether Iloprost treatment summer suspension modifies systemic cytokines levels, cutaneous thermal properties and functional response to a cold-induced stress in patients affected by systemic sclerosis (SSc).
Methods:
Twenty-eight patients fulfilling the American College of Rheumatology (ACR) criteria for SSc were included in the study. Patients recorded number, duration and pain-severity of Raynaud phenomenon (RP). Pain-severity was determined by a visual analog scale. Cytokines expression and production in peripheral blood mononuclear cells and serum were evaluated by RT-PCR and ELISA assay. Basal finger temperature (Tb), distal-dorsal difference temperature (DTdd) and thermal recovery time (tr) from cold stress were measured by means of functional infrared imaging (fIR). Measurements were performed in late spring, during routine Iloprost therapy (1-3 days infusion of 0.5-2 ng/kg every month), and in late summer after a therapy-withdrawal period.
Results:
Deterioration of SSc patients' skin thermal properties was observed in the period of therapy withdrawal (Tb reduction and tr enhancement; no DTdd differences) despite the improvement in symptoms of RP. A reduction in IL-12/23p40 gene expression was recorded after therapy withdrawal and a direct correlation between IL-12/23p40 and IL-23p19 gene expression was observed, stronger after therapy suspension.
Conclusion:
Our data suggest that Iloprost treatment summer suspension may induce the loss of the therapy beneficial effect on microcirculation despite the objective reduction of RP, thus favouring a continuous use of Iloprost in absence of severe side effects. Iloprost showed to modulate only IL-23 expression corroborating the idea that this cytokine is crucial for SSc development and progression.
