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3.2 A, B: Proteome profiler arrays with supernatants from sorted lung eosinophils and synovial eosinophils of OVA+SIA mice, 9 days after K/BxN serum transfer, collected after 48h culture (A) and relative levels (integrated pixel density) of the detected cytokines (B). Data are shown as mean ± SEM.
Source publication
Rheumatoid arthritis (RA) is a systemic and chronic inflammatory disease, involving primarily synovial joints. Once inflammation is established, RA patients don´t have the capability to resolve spontaneously. Many projects aim to delineate anti-inflammatory, regulatory mediators and pathways in RA to uncover potential regulatory-targets for RA mana...
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Background
A pre-specified meta-analysis of individual patient data from the 52-week METREX and METREO trials, which investigated mepolizumab for chronic obstructive pulmonary disease (COPD) in patients with blood eosinophil counts ≥150 cells/µL (screening) or ≥300 cells/µL (prior year) and frequent exacerbations, enables more robust characterizati...
