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1-J.F. Cohnheim; 2-his model of inflammation and 3-margination of white blood cells observed in this model (2-3 images by V.J. Utekhin & L.P. Churilov); 4-K. von Rokitansky; 5-S. Stricker; 6-R. Paltauf; 7-A. Biedl morphological findings are descriptive and insufficient for comprehension of the diseases, especially because of importance of chemical (humoral) communication of cells, undetectable by microscopes of that period. First director of this Institute, Salomon Stricker (1834-1898) realized the necessity of close collaboration between experimental pathologists and clinicians, which idea was too brave for many of his clinical colleagues (Peterlik 2004). Later this Institute due to efforts of Arthur Biedl (1869-1933) and Richard Paltauf (18581924) made next step and started research in the field of Pathochemistry (see below).

1-J.F. Cohnheim; 2-his model of inflammation and 3-margination of white blood cells observed in this model (2-3 images by V.J. Utekhin & L.P. Churilov); 4-K. von Rokitansky; 5-S. Stricker; 6-R. Paltauf; 7-A. Biedl morphological findings are descriptive and insufficient for comprehension of the diseases, especially because of importance of chemical (humoral) communication of cells, undetectable by microscopes of that period. First director of this Institute, Salomon Stricker (1834-1898) realized the necessity of close collaboration between experimental pathologists and clinicians, which idea was too brave for many of his clinical colleagues (Peterlik 2004). Later this Institute due to efforts of Arthur Biedl (1869-1933) and Richard Paltauf (18581924) made next step and started research in the field of Pathochemistry (see below).

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A paper describes the main events and periods in the history of Pathophysiology as a curriculum element and research area. The national schools of Pathophysiology in Russia, continental Europe, Asia and British-North American world are compared, their history discussed. The evolution of Pathophysiology towards Systemic Pathobiology, its crisis and...

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Context 1
... Virchow expressed the whole atmosphere of the epoch in the following phrase: "If a pathological anato- mist does not want to settle for his dead material, closed in simple spatial relations, he is left with no choice but to become at the same time a pathological physiologist" (Virchow 1858). And no surprise that it was his closest pupil, Julius Friedrich Cohnheim (1839-1884), who became first one in the West and developed biomicro- scopy of alive experimental objects by the methods we still use in teaching course of Pathophysiology ( Figure 5). His Department of Anatomic and General Pathology at Kiel (1868) was at least partially pathophysiological one. ...
Context 2
... this entity Patho- physiology intermingles with Pathochemistry, Immuno- pathology, Clinical Genetics, Pathomorphology and other concrete facets of Pathology. In outer circle of this system there are Clinical Disciplines (Figure 15). Moreover, the substances in metabolism are not only bricks or fuel by their roles, but signals or better to say messages as well. ...

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... This analytic-synthetic description of etiopathogenesis arouse broader interest. It was referred to as "…around 100 of mosaic blocks, interplaying in all nosological forms, like elements of Mendeleyev's table adjoined in any substance, so they give strong impetus to systemic autonomous analysis of clinical and pathophysiological problems by students…" (Churilov 2015). ...
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