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Cerebellar Purkinje cell show inverse stochastic resonance (ISR) A. Whole-cell patch-clamp recording from a Purkinje cell in a cerebellar slice, showing current injection of 1!! noise waveform periods with increasing amplitude, and recorded membrane potential ! !. Holding current is !! = ! −290!". The firing rate of the Purkinje cell (PC) is reduced for intermediary noise amplitude. B. Firing frequency during 1!! noise injection vs. noise amplitude σ corresponding to the trace in A. Error bars are standard deviation. The firing rate is minimum for σ=100pA. C. The ISR is observed in all Purkinje cells tested. Summary of optimal noise amplitude σ= 152.60 ± 64.42 pA (n=19). D. ISR curve of a different PC, generated with a current injection protocol of continuously changing noise amplitude and for a series of holding current, exploring the full range of the f-I curve (E). The firing rate is most reduced when the cell is hyperpolarized to the edge of the f-I curve step. The optimal noise amplitude for inhibition of firing is σ=200pA. E. Frequency vs. current generated with steps current injection of 1!!. The color code corresponds to the region explored for the ISR curve in D. 

Cerebellar Purkinje cell show inverse stochastic resonance (ISR) A. Whole-cell patch-clamp recording from a Purkinje cell in a cerebellar slice, showing current injection of 1!! noise waveform periods with increasing amplitude, and recorded membrane potential ! !. Holding current is !! = ! −290!". The firing rate of the Purkinje cell (PC) is reduced for intermediary noise amplitude. B. Firing frequency during 1!! noise injection vs. noise amplitude σ corresponding to the trace in A. Error bars are standard deviation. The firing rate is minimum for σ=100pA. C. The ISR is observed in all Purkinje cells tested. Summary of optimal noise amplitude σ= 152.60 ± 64.42 pA (n=19). D. ISR curve of a different PC, generated with a current injection protocol of continuously changing noise amplitude and for a series of holding current, exploring the full range of the f-I curve (E). The firing rate is most reduced when the cell is hyperpolarized to the edge of the f-I curve step. The optimal noise amplitude for inhibition of firing is σ=200pA. E. Frequency vs. current generated with steps current injection of 1!!. The color code corresponds to the region explored for the ISR curve in D. 

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Figure I-4. Ion dynamics of potassium, sodium and chloride in single...
Figure IV-2. Experimental characterization of Purkinje cell bistability...
Figure IV-3. aEIF model fitting procedure to Purkinje cell experimental...
Figure IV-4. Hysteresis and ISR of the aEIF model A Voltage response of...
+20 Figure IV-5. Bifurcation diagram and phase plane of the aEIF model A....
Modeling of single cell and network phenomena of the nervous system : ion dynamics during epileptic oscillations and inverse stochastic resonance
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  • Nov 2015
In this thesis we used dynamical systems methods and numericalsimulations to study the mechanisms of epileptic oscillations associated with ionconcentration changes and cerebellar Purkinje cell bimodal behavior. The general issue in this work is the interplay between single neuron intrinsicproperties and synaptic input structure controlling the neu...
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