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For the fun of science: A discussion with John E. Casida
... Certainly, John was creative and productive by any measure, with over 30 patents and 800 peer-reviewed publications, and an exceptionally high citation index in diverse fields. Repeatedly he solved timely problems in agricultural chemistry and pesticide toxicology, and illuminated a path toward impactful and fruitful research in fundamental biology (Hammock & Casida 1998;Komives 2018; Wing 2019). His career spanned modern pesticide science and technology. ...
... We are sure John appreciated the tremendous contribution his career made to pesticide toxicology, the environment, human health and agriculture. However, in talking to numerous Casida alumni, the conclusion was that he did it for the fun of science (Hammock & Casida 1998 Casida. His work focused on synthesis, evaluation and metabolism chemistry of mimics of insect juvenile hormones as green pesticides. ...
John Edward Casida's research in pesticide toxicology led to more effective agricultural chemicals that are far safer for human and environmental health. He used pesticides as probes for his fundamental studies of metabolism and mode of action, resulting in great insight into biological chemistry and the underlying mechanisms of regulatory biology, ranging from voltage-gated sodium channels, through the ryanodine receptor and calcium regulation, the gamma-aminobutyric acid (GABA)-gated chloride channel, to the nicotinic acetylcholine receptors. These discoveries, among many others, have had a profound impact on pharmacology and toxicology. His research career started with the introduction of DDT into agricultural practice and continued to assist in the development of many pesticides that dominate the market today. John Casida trained multiple generations of toxicologists who obtained leading positions in government, industry and academics. He spent many of his formative years in Madison, Wisconsin, where he entered the University of Wisconsin, received his BS, MS and PhD and then joined the faculty to become a full professor six years later. He then moved to the Entomology Department at the University of California, Berkeley where he remained active in teaching and research until his death. He loved laboratory science and this, coupled with insatiable curiosity and a gift for finding the unexpected, led to papers from his laboratory sparkling with creativity. He similarly loved teaching at all levels and had just finished grading the final examination in his toxicology class at the time of his passing. John won numerous national and international awards and is widely viewed as the premiere pesticide toxicologist.
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