Amanda Kalliopi Emma HornsbyCardiff University | CU · School of Biosciences
Amanda Kalliopi Emma Hornsby
PhD Molecular Neurobiology
About
10
Publications
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195
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Introduction
Studying the effects of temporal feeding patterns on adult hippocampal neurogenesis and hippocampal-dependent learning and memory, in rodents. Elucidating whether any effects are dependent on ghrelin.
Additional affiliations
Education
April 2014 - March 2018
September 2009 - September 2010
Independent Researcher
Field of study
- Immunology
September 2005 - June 2008
Publications
Publications (10)
New neurones are generated throughout life in the mammalian brain in a process known as adult hippocampal neurogenesis (AHN). Since this phenomenon grants a high degree of neuroplasticity influencing learning and memory, identifying factors that regulate AHN may be important for ameliorating age‐related cognitive decline. Calorie restriction (CR) h...
New neurones are generated throughout life in the mammalian brain in a process known as adult hippocampal neurogenesis (AHN). Since this phenomenon grants a high degree of neuroplasticity influencing learning and memory and mood related behaviour, identifying factors that regulate AHN may be important for ameliorating age-related cognitive decline...
Blood-borne factors regulate adult hippocampal neurogenesis and cognition in mammals. We report that elevating circulating unacylated-ghrelin (UAG), using both pharmacological and genetic methods, reduced hippocampal neurogenesis and plasticity in mice. Spatial memory impairments observed in ghrelin-O-acyl transferase-null (GOAT -/-) mice that lack...
The ageing and degenerating brain show deficits in neural stem/progenitor cell (NSPC) plasticity that are accompanied by impairments in olfactory discrimination. Emerging evidence suggests that the gut‐hormone ghrelin plays an important role in protecting neurones, promoting synaptic plasticity and increasing hippocampal neurogenesis in the adult b...
Blood-borne factors regulate adult hippocampal neurogenesis (AHN) and cognition in mammals, albeit via mechanisms that are poorly understood. We report that elevating circulating unacylated-ghrelin (UAG), using both pharmacological and genetic methods, reduced hippocampal neurogenesis and plasticity in mice. Spatial memory impairments observed in G...
The beneficial effects of calorie restriction (CR) have been described at both organismal and cellular levels in multiple organs. However, our understanding of the causal mediators of such hormesis is poorly understood, particularly in the context of higher brain function. Here, we show that the receptor for the orexigenic hormone acyl-ghrelin, the...
An important link exists between intact metabolic processes and normal cognitive functioning; however, the underlying mechanisms remain unknown. There is accumulating evidence that the gut hormone ghrelin, an orexigenic peptide that is elevated during calorie restriction (CR) and known primarily for stimulating growth hormone release, has important...
Questions
Questions (4)
I'm looking for a good oligodendrocyte antibody to do some double stain with BrdU in rat and mouse brain tissue. What do people recommend?
I have previously used Santa Cruz sc-8066 DCX antibody, which has been discontinued, and need a replacement for it. I will be staining rodent brain tissue with it.
Any recommendations would be greatly appreciated.
Hi All,
I am having trouble analysing the A-beta plaques in the Ni-DAB stained mouse hippocampus sections. The background is quite dark, so I'm having trouble using ImageJ to do plaque count. Can anyone suggest a method to help with analysis?
Kind regards,
Amanda Hornsby
The cryostat that I have available to me can only section up to a thickness of 60um. Has anyone done successful spine analysis on sections of this thickness?
Also, the slides that I want to use to mount my sections on are SuperFrost+ charged slides, would these be adequate to use or are gelatin coated slides better?